neuroscience Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions and disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, development ...

and

neurology Neurology (from el, wikt:νεῦρον, νεῦρον (neûron), "string, nerve" and the suffix wikt:-logia, -logia, "study of") is the branch of specialty (medicine), medicine dealing with the diagnosis and treatment of all categories of co ...

, a trigger zone is an area in the body, or of a cell, in which a specific type of stimulation triggers a specific type of response. The term was first used in this context around 1914 by Hugh T. Patrick, who was writing about trigeminal neuralgia, a condition in which pain fibers in the

trigeminal nerve In neuroanatomy, the trigeminal nerve ( lit. ''triplet'' nerve), also known as the fifth cranial nerve, cranial nerve V, or simply CN V, is a cranial nerve responsible for sensation in the face and motor functions such as biting and chewin ...

become hypersensitive. In people with trigeminal neuralgia, even a light touch to some part of the body—often a tooth or a part of the face—can give rise to an extended period of excruciating pain. Patrick referred to the sensitive part of the body as the "dolorogenic zone", and used the term "trigger zone" as a simpler equivalent. Through the 1920s and 1930s the term came into steadily wider use, but almost always in the context of neuralgia. Starting in the late 1930s, other types of stimulation and other types of responses were characterized as having the properties of a trigger zone. In 1940, for example, Morison and Dempsey observed that a small area of the

cerebral cortex The cerebral cortex, also known as the cerebral mantle, is the outer layer of neural tissue of the cerebrum of the brain in humans and other mammals. The cerebral cortex mostly consists of the six-layered neocortex, with just 10% consisting of ...

could be triggered when electrical stimulation would evoke widespread activity in other parts of the cerebral cortex. In 1944 Paul Wilcox described triggering of epileptic seizure by electrical stimulation of another area of the cerebral cortex. The chemoreceptor trigger zone is within the area postrema of the

medulla oblongata The medulla oblongata or simply medulla is a long stem-like structure which makes up the lower part of the brainstem. It is anterior and partially inferior to the cerebellum. It is a cone-shaped neuronal mass responsible for autonomic (involun ...

in which many types of chemical stimulation can provoke nausea and

vomiting Vomiting (also known as emesis and throwing up) is the involuntary, forceful expulsion of the contents of one's stomach through the mouth and sometimes the Human nose, nose. Vomiting can be the result of ailments like Food-poisoning, foo ...

. This area was first identified and named in 1951 by Herbert L. Borison and Kenneth R. Brizzee. Parts of cells, rather than parts of the body, can also behave as trigger zones. The axon hillock of a

neuron A neuron, neurone, or nerve cell is an electrically excitable cell that communicates with other cells via specialized connections called synapses. The neuron is the main component of nervous tissue in all animals except sponges and placozoa. N ...

possesses the highest density of voltage-gated Na⁺ channels, and is therefore the region where it is easiest for the

action potential An action potential occurs when the membrane potential of a specific cell location rapidly rises and falls. This depolarization then causes adjacent locations to similarly depolarize. Action potentials occur in several types of animal cells, ...

threshold Threshold may refer to: Architecture * Threshold (door), the sill of a door Media * ''Threshold'' (1981 film) * ''Threshold'' (TV series), an American science fiction drama series produced during 2005-2006 * "Threshold" (''Stargate SG-1''), ...

to be reached.

References

{{reflist Neurophysiology Electrophysiology Voltage-gated ion channels Medulla oblongata Cellular neuroscience Cellular processes Membrane biology