Tricetin is a
flavone, a type of flavonoid. It is a rare aglycone found in the pollen of members of the Myrtaceae, subfamily
Leptospermoideae, such as ''
Eucalyptus globulus
''Eucalyptus globulus'', commonly known as southern blue gum or blue gum, is a species of tall, evergreen tree endemic to southeastern Australia. This ''Eucalyptus'' species has mostly smooth bark, juvenile leaves that are whitish and waxy on ...
''. This compound shows anticancer effects on human breast adenocarcinoma
MCF-7
MCF-7 is a breast cancer cell line isolated in 1970 from a 69-year-old White woman. MCF-7 is the acronym of Michigan Cancer Foundation-7, referring to the institute in Detroit where the cell line was established in 1973 by Herbert Soule and co-wor ...
cells. Moreover. a potent anti-inflammatory effect of tricetin has also been demonstrated in a model of acute pancreatitis.
This observation was explained by the compound's radical scavenging effects, its inhibitory effect on the DNA damage sensor enzyme
poly (ADP-ribose) polymerase-1 (PARP1) and PARP1-mediated cell death and suppression of inflammatory gene expression.
See also
*
Tricin synthase produces
tricin
Tricin is a chemical compound. It is an O-methylated flavone, a type of flavonoid. It can be found in rice bran and sugarcane.
Glycosides
* Tricin 4'-glucoside (Tricin-4'-O-beta-D-glucopyranaoside, CAS number 71855-50-0)
* Tricin 5-glucoside (T ...
or tricetin 3′,5′-dimethyl ether
*
Tricetin 3′,4′,5′-''O''-trimethyltransferase
References
Flavones
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