Tribendimidine is a broad-spectrum

anthelmintic Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. They may a ...

agent developed in

China China, officially the People's Republic of China (PRC), is a country in East Asia. It is the world's most populous country, with a population exceeding 1.4 billion, slightly ahead of India. China spans the equivalent of five time zones and ...

, at the National Institute of Parasitic Diseases in

Shanghai Shanghai (; , , Standard Mandarin pronunciation: ) is one of the four direct-administered municipalities of the People's Republic of China (PRC). The city is located on the southern estuary of the Yangtze River, with the Huangpu River flow ...

. It is a derivative of amidantel.Free full text
In

clinical trial Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietar ...

s, it was highly effective in treating

ankylostomiasis Hookworm infection is an infection by a type of intestinal parasite known as a hookworm. Initially, itching and a rash may occur at the site of infection. Those only affected by a few worms may show no symptoms. Those infected by many worms may e ...

ascariasis Ascariasis is a disease caused by the parasitic roundworm ''Ascaris lumbricoides''. Infections have no symptoms in more than 85% of cases, especially if the number of worms is small. Symptoms increase with the number of worms present and may in ...

and

enterobiasis Pinworm infection (threadworm infection in the UK), also known as enterobiasis, is a human parasitic disease caused by the pinworm. The most common symptom is itching in the anal area. The period of time from swallowing eggs to the appearance ...

. It is also effective against

clonorchiasis Clonorchiasis is an infectious disease caused by the Chinese liver fluke (''Clonorchis sinensis'') and two related species. Clonorchiasis is a known risk factor for the development of cholangiocarcinoma, a neoplasm of the biliary system. Sympt ...

. However, animal studies suggest it is ineffective in treating ''

Schistosoma mansoni A paired couple of ''Schistosoma mansoni''. ''Schistosoma mansoni'' is a water-borne parasite of humans, and belongs to the group of blood flukes (''Schistosoma''). The adult lives in the blood vessels ( mesenteric veins) near the human inte ...

'' or ''

Fasciola hepatica ''Fasciola hepatica'', also known as the common liver fluke or sheep liver fluke, is a parasitic trematode (fluke or flatworm, a type of helminth) of the class Trematoda, phylum Platyhelminthes. It infects the livers of various mammals, inc ...

'' disease. The drug has also performed well in trials against

opisthorchiasis Opisthorchiasis is a parasitic disease caused by certain species of genus '' Opisthorchis'' (specifically, '' Opisthorchis viverrini'' and '' Opisthorchis felineus''). Chronic infection may lead to cholangiocarcinoma, a cancer of the bile ducts. ...

, curing about 70% of cases. Tribendimidine is manufactured by

Shandong Xinhua Pharmaceutical Company Limited Shandong ( , ; ; alternately romanized as Shantung) is a coastal province of the People's Republic of China and is part of the East China region. Shandong has played a major role in Chinese history since the beginning of Chinese civilizatio ...

Zibo Zibo (, ) is a prefecture-level city in central Shandong province, China. It borders the provincial capital Jinan to the west, Tai'an to the southwest, Linyi to the south, Weifang to the east, Dongying to the northeast, and Binzhou to the nor ...

Shandong Shandong ( , ; ; alternately romanized as Shantung) is a coastal province of the People's Republic of China and is part of the East China region. Shandong has played a major role in Chinese history since the beginning of Chinese civilizati ...

. It was approved by the China Food and Drug Administration in 2007.

References

Anthelmintics Amidines Imines Nicotinic agonists {{antimicrobial-stub