The enzyme Triacylglycerol lipase (also Triglyceride lipase, EC 3.1.1.3;systematic name triacylglycerol acylhydrolase) catalyses the hydrolysis of ester linkages of
triglycerides
A triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids (from ''tri-'' and ''glyceride'').
Triglycerides are the main constituents of body fat in humans and other vertebrates, as we ...
:
:
triacylglycerol
A triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids (from ''tri-'' and ''glyceride'').
Triglycerides are the main constituents of body fat in humans and other vertebrates, as we ...
+ H
2O
diacylglycerol
A diglyceride, or diacylglycerol (DAG), is a glyceride consisting of two fatty acid chains covalently bonded to a glycerol molecule through ester linkages. Two possible forms exist, 1,2-diacylglycerols and 1,3-diacylglycerols. DAGs can act as sur ...
+ a
carboxylate
In organic chemistry, a carboxylate is the conjugate base of a carboxylic acid, (or ). It is an ion with negative charge.
Carboxylate salts are salts that have the general formula , where M is a metal and ''n'' is 1, 2,...; ''carboxylat ...
These lipases are widely distributed in animals, plants and prokaryotes. This family was also called class 3 lipases as they are only distantly related to other lipase families.
Human proteins containing this domain
DAGLA;
DAGLB;
LOC221955
LOC, L.O.C., Loc, LoC, or locs may refer to:
Places
* Lóc, a village in Sângeorgiu de Pădure, Mureș County, Romania
* Lócs, a village in Vas county, Hungary
* Line of Contact, meeting place of Western and Eastern Allied forces at the e ...
;
The
pancreatic
The pancreas is an Organ (anatomy), organ of the digestive system and endocrine system of vertebrates. In humans, it is located in the abdominal cavity, abdomen behind the stomach and functions as a gland. The pancreas is a mixed or heterocrine ...
enzyme acts only on an ester-water interface.
Nomenclature
Other names include ''lipase'', ''butyrinase'', ''tributyrinase'', ''Tween hydrolase'', ''steapsin'', ''triacetinase'', ''tributyrin esterase'', ''Tweenase'', ''amno N-AP'', ''Takedo 1969-4-9'', ''Meito MY 30'', ''Tweenesterase'', ''GA 56'', ''capalase L'', ''triglyceride hydrolase'', ''triolein hydrolase'', ''tween-hydrolyzing esterase'', ''amano CE'', ''cacordase'', ''triglyceridase'', ''triacylglycerol ester hydrolase'', ''amano P'', ''amano AP'', ''PPL'', ''glycerol-ester hydrolase'', ''GEH'', ''meito Sangyo OF lipase'', ''hepatic lipase'', ''lipazin'', ''post-heparin plasma protamine-resistant lipase'', ''salt-resistant post-heparin lipase'', ''heparin releasable hepatic lipase'', ''amano CES'', ''amano B'', ''tributyrase'', ''triglyceride lipase'', ''liver lipase'', ''hepatic monoacylglycerol acyltransferase'').
See also
*
Pancreatic lipase
Triglyceride lipases () are a family of lipolytic enzymes that hydrolyse ester linkages of triglycerides. Lipases are widely distributed in animals, plants and prokaryotes.
At least three tissue-specific isozymes exist in higher vertebrates, p ...
*
Gastric lipase
The stomach is a muscular, hollow organ in the gastrointestinal tract of humans and many other animals, including several invertebrates. The stomach has a dilated structure and functions as a vital organ in the digestive system. The stomach ...
*
Lingual lipase
Lingual lipase is a member of a family of digestive enzymes called triacylglycerol lipases, EC 3.1.1.3, that use the catalytic triad of aspartate, histidine, and serine to hydrolyze medium and long-chain triglycerides into partial glycerides and ...
References
External links
*
EC 3.1.1
Protein domains
Protein families
Peripheral membrane proteins
{{InterPro content, IPR002921