Triacsin C is an
inhibitor
Inhibitor or inhibition may refer to:
In biology
* Enzyme inhibitor, a substance that binds to an enzyme and decreases the enzyme's activity
* Reuptake inhibitor, a substance that increases neurotransmission by blocking the reuptake of a neurotra ...
of
long fatty acyl CoA synthetase
Long may refer to:
Measurement
* Long, characteristic of something of great duration
* Long, characteristic of something of great length
* Longitude (abbreviation: long.), a geographic coordinate
* Longa (music), note value in early music mensur ...
that has been isolated from ''
Streptomyces aureofaciens
''Kitasatospora aureofaciens'' is a species of ''Kitasatospora'', and the source of many tetracycline antibiotics. The organism was first isolated at Sanborn Field on the University of Missouri campus in Columbia, Missouri, US; the site became a ...
''.
It blocks β-cell
apoptosis
Apoptosis (from grc, ἀπόπτωσις, apóptōsis, 'falling off') is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes incl ...
, induced by fatty acids (lipoapoptosis) in a rat model of
obesity. In addition, it blocks the de novo synthesis of
triglycerides,
diglycerides, and
cholesterol esters, thus interfering with
lipid metabolism.
In addition, triacsin C is a
vasodilator
Vasodilation is the widening of blood vessels. It results from relaxation of smooth muscle cells within the vessel walls, in particular in the large veins, large arteries, and smaller arterioles. The process is the opposite of vasoconstriction, ...
.
[
Inhibition of lipid metabolism reduces/removes lipid droplets from HuH7 cells. In ]hepatitis C
Hepatitis C is an infectious disease caused by the hepatitis C virus (HCV) that primarily affects the liver; it is a type of viral hepatitis. During the initial infection people often have mild or no symptoms. Occasionally a fever, dark urine, a ...
infected HuH7 cells, this reduction/removal of lipid droplets significantly reduces virion formation and release.
General chemical description
Triacsin C belongs to a family of fungal metabolites all having an 11-carbon alkenyl chain with a common ''N''-hydroxytriazene moiety at the terminus. Due to the ''N''-hydroxytriazene group, triacsin C has acidic properties and may be considered a polyunsaturated fatty acid analog
Analog or analogue may refer to:
Computing and electronics
* Analog signal, in which information is encoded in a continuous variable
** Analog device, an apparatus that operates on analog signals
*** Analog electronics, circuits which use analo ...
.
Triacsin C was discovered by Keizo Yoshida and other Japanese scientists in 1982 in a culture of the microbe ''Streptomyces aureofaciens''.[ They identified it as a ]vasodilator
Vasodilation is the widening of blood vessels. It results from relaxation of smooth muscle cells within the vessel walls, in particular in the large veins, large arteries, and smaller arterioles. The process is the opposite of vasoconstriction, ...
.
See also
* Fatty acid degradation#Activation_and_transport_into_mitochondria
* Fatty acyl CoA synthetase
References
{{Reflist
Ligase inhibitors
Nitrosamines
Hydrazones
Polyenes