Tremorine is a drug which is used in scientific research to produce
tremor
A tremor is an involuntary, somewhat rhythmic, muscle contraction and relaxation involving oscillations or twitching movements of one or more body parts. It is the most common of all involuntary movements and can affect the hands, arms, eyes, fa ...
in animals. This is used for the development of drugs for the treatment of
Parkinson's disease
Parkinson's disease (PD), or simply Parkinson's, is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms usually emerge slowly, and as the disease worsens, non-motor symptoms becom ...
, as tremor is a major symptom which is treated by anti-Parkinson's drugs.
Beta blocker
Beta blockers, also spelled β-blockers, are a class of medications that are predominantly used to manage cardiac arrhythmia, abnormal heart rhythms, and to protect the heart from a second myocardial infarction, heart attack after a first heart ...
s are also effective in counteracting the effects of tremorine.
History
Tremorine was first reported by Everett et al. in 1956-57.
[Blockus, L. E. and Everett, G. M. (January 1957). "Tremor producing drug 1,4 di-pyrrolidino-2-butyne (Tremorine)", ''Federation Proceedings'' v. 16(1), p. 283.]
References
See also
*
Oxotremorine
Oxotremorine is a drug that acts as a selective muscarinic acetylcholine receptor agonist.
Oxotremorine produces ataxia, tremor and spasticity, similar to those symptoms seen in Parkinsonism, and has thus become a research tool in experimental s ...
Parkinson's disease
Alkyne derivatives
Pyrrolidines
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