Transcription initiation protein SPT3 homolog is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...

that in humans is encoded by the ''SUPT3H''

gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...

Interactions

Transcription initiation protein SPT3 homolog has been shown to

interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...

with

GCN5L2 __NOTOC__ Histone acetyltransferase KAT2A is an enzyme that in humans is encoded by the ''KAT2A'' gene. Interactions GCN5L2 has been shown to interact with: * DDB1, * Ku70, * Ku80 Ku80 is a protein that, in humans, is encoded by the ''XRCC5 ...

TAF6L TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L is an enzyme that in humans is encoded by the ''TAF6L'' gene. Function Initiation of transcription by RNA polymerase II requires the activities of more t ...

TADA3L Transcriptional adapter 3-like is a protein that in humans is encoded by the ''TADA3'' gene. Cytogenetic location: 3p25.3 Function Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated ge ...

TAF5L TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L is an enzyme that in humans is encoded by the ''TAF5L'' gene. Function The product of this gene belongs to the WD-repeat TAF5 family of proteins. This g ...

SF3B3 Splicing factor 3B subunit 3 is a protein that in humans is encoded by the ''SF3B3'' gene. This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U ...

SUPT7L STAGA complex 65 subunit gamma is a protein that in humans is encoded by the ''SUPT7L'' gene. Model organisms Model organisms have been used in the study of SUPT7L function. A conditional knockout mouse line, called ''Supt7ltm1a(EUCOMM)Wtsi'' ...

Myc ''Myc'' is a family of regulator genes and proto-oncogenes that code for transcription factors. The ''Myc'' family consists of three related human genes: ''c-myc'' (MYC), ''l-myc'' ( MYCL), and ''n-myc'' (MYCN). ''c-myc'' (also sometimes refe ...

TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa, also known as TAF9, is a protein that in humans is encoded by the ''TAF9'' gene. Function Initiation of transcription by RNA polymerase II requires the activities ...

Transformation/transcription domain-associated protein Transformation/transcription domain-associated protein, also known as TRRAP, is a protein that in humans is encoded by the ''TRRAP'' gene. TRRAP belongs to the phosphatidylinositol 3-kinase-related kinase protein family. Function TRRAP is an ad ...

TAF12 Transcription initiation factor TFIID subunit 12 is a protein that in humans is encoded by the ''TAF12'' gene. Function Control of transcription by RNA polymerase II involves the basal transcription machinery, which is a collection of proteins ...

TAF10 Transcription initiation factor TFIID subunit 10 is a protein that in humans is encoded by the ''TAF10'' gene. Function Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coo ...

TAF4 Transcription initiation factor TFIID subunit 4 is a protein that in humans is encoded by the ''TAF4'' gene. Function Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordi ...

and

DDB1 DNA damage-binding protein 1 is a protein that in humans is encoded by the ''DDB1'' gene. Gene The gene's position is on chromosome 11q12-q13. Protein The DDB1 gene encodes the large subunit of DNA damage-binding protein, a heterodimer composed ...

Model organisms

Model organism A model organism (often shortened to model) is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the model organism will provide insight into the workin ...

s have been used in the study of SUPT3H function. A conditional

knockout mouse A knockout mouse, or knock-out mouse, is a genetically modified mouse (''Mus musculus'') in which researchers have inactivated, or "knocked out", an existing gene by replacing it or disrupting it with an artificial piece of DNA. They are importan ...

line called ''Supt3^{tm1a(EUCOMM)Hmgu}'' was generated at the

Wellcome Trust Sanger Institute The Wellcome Sanger Institute, previously known as The Sanger Centre and Wellcome Trust Sanger Institute, is a non-profit British genomics and genetics research institute, primarily funded by the Wellcome Trust. It is located on the Wellcome G ...

. Male and female animals underwent a standardized

phenotypic screen In genetics, the phenotype () is the set of observable characteristics or traits of an organism. The term covers the organism's morphology or physical form and structure, its developmental processes, its biochemical and physiological proper ...

to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping

Interactions

Model organisms

References

Further reading