Trafermin (brand name Fiblast), also known as recombinant human basic fibroblast growth factor (rhbFGF), is a
recombinant form of human
basic fibroblast growth factor (bFGF) which is marketed in
Japan
Japan ( ja, 日本, or , and formally , ''Nihonkoku'') is an island country in East Asia. It is situated in the northwest Pacific Ocean, and is bordered on the west by the Sea of Japan, while extending from the Sea of Okhotsk in the north ...
as a
topical
A topical medication is a medication that is applied to a particular place on or in the body. Most often topical medication means application to body surfaces such as the skin or mucous membranes to treat ailments via a large range of classes ...
spray
Spray or spraying commonly refer to:
* Spray (liquid drop)
** Aerosol spray
** Blood spray
** Hair spray
** Nasal spray
** Pepper spray
** PAVA spray
** Road spray or tire spray, road debris kicked up from a vehicle tire
** Sea spray, refers to ...
for the treatment of
skin ulcer
An ulcer is a sore on the skin or a mucous membrane, accompanied by the disintegration of tissue. Ulcers can result in complete loss of the epidermis and often portions of the dermis and even subcutaneous fat. Ulcers are most common on the skin of ...
s.
It is also currently in preregistration for the treatment of
periodontitis
Periodontal disease, also known as gum disease, is a set of inflammatory conditions affecting the tissues surrounding the teeth. In its early stage, called gingivitis, the gums become swollen and red and may bleed. It is considered the main caus ...
.
As a recombinant form of bFGF, trafermin is a
potent agonist
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...
of the
FGFR1,
FGFR2,
FGFR3, and
FGFR4.
The drug has been marketed in Japan since June 2001.
[Spaccapelo, L. RATIONALE FOR BASIC FGF IN WOUND HEALING AND REVIEW OF THERAPEUTIC APPLICATIONS.]
References
External links
Trafermin - AdisInsight
Growth factors
Human proteins
Recombinant proteins
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