The Tobamovirus internal ribosome entry site (IRES) is an element that allows cap and end-independent
translation
Translation is the communication of the Meaning (linguistic), meaning of a #Source and target languages, source-language text by means of an Dynamic and formal equivalence, equivalent #Source and target languages, target-language text. The ...
of
mRNA
In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of Protein biosynthesis, synthesizing a protein.
mRNA is ...
in the host cell. The
IRES achieves this by mediating the internal initiation of translation by recruiting a
ribosomal
Ribosomes ( ) are macromolecular machines, found within all cells, that perform biological protein synthesis (mRNA translation). Ribosomes link amino acids together in the order specified by the codons of messenger RNA (mRNA) molecules to fo ...
43S pre-initiation complex directly to the initiation
codon
The genetic code is the set of rules used by living cells to translate information encoded within genetic material ( DNA or RNA sequences of nucleotide triplets, or codons) into proteins. Translation is accomplished by the ribosome, which links ...
and eliminates the requirement for the
eukaryotic initiation factor Eukaryotic initiation factors (eIFs) are Protein, proteins or Protein complex, protein complexes involved in the initiation phase of eukaryotic translation. These proteins help stabilize the formation of ribosomal preinitiation complexes around the ...
, eIF4F.
See also
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Mnt IRES
The Mnt internal ribosome entry site (Internal ribosome entry site, IRES) is an cis-regulatory element, RNA element. Mnt is a transcriptional repressor related to the Myc/Mad family of transcription factors. It is thought that this IRES allows eff ...
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N-myc IRES
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TrkB IRES
The TrkB internal ribosome entry site (IRES) is an RNA element which is present in the 5' UTR sequence of the mRNA. TrkB is a neurotrophin receptor which is essential for the development and maintenance of the nervous system. The internal ribosom ...
References
External links
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Cis-regulatory RNA elements
Tobamovirus
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