Thiocarlide (or tiocarlide or isoxyl) is a
thiourea drug used in the treatment of
tuberculosis, inhibiting synthesis of
oleic acid and
tuberculostearic acid
Tuberculostearic acid is a saturated fatty acid produced by Actinomycetales bacteria.
The name 'Tuberculostearic acid' was coined because it was first isolated in 1927 from the bacteria ''Mycobacterium tuberculosis
''Mycobacterium tuberculosis ...
.
Thiocarlide has considerable anti
mycobacteria
''Mycobacterium'' is a genus of over 190 species in the phylum Actinomycetota, assigned its own family, Mycobacteriaceae. This genus includes pathogens known to cause serious diseases in mammals, including tuberculosis ('' M. tuberculosis'') and ...
l activity ''in vitro'' and is effective against multi-drug resistant strains of ''
Mycobacterium tuberculosis
''Mycobacterium tuberculosis'' (M. tb) is a species of pathogenic bacteria in the family Mycobacteriaceae and the causative agent of tuberculosis. First discovered in 1882 by Robert Koch, ''M. tuberculosis'' has an unusual, waxy coating on its c ...
''.
Isoxyl inhibits ''M. bovis'' with six hours of exposure, which is similar to
isoniazid and
ethionamide, two other prominent anti-TB drugs. Unlike these two drugs, however, isoxyl also partially inhibits the synthesis of fatty acids.
Thiocarlide was developed by a
Belgian company,
Continental Pharma
Continental may refer to:
Places
* Continent, the major landmasses of Earth
* Continental, Arizona, a small community in Pima County, Arizona, US
* Continental, Ohio, a small town in Putnam County, US
Arts and entertainment
* ''Continental'' ( ...
S.A. Belgo-Canadienne in
Brussels, Belgium. The head researcher was Professor
N. P. Buu-Hoi, head of Continental Pharma's Research Division.
References
Antibiotics
Thioureas
Phenol ethers
Anti-tuberculosis drugs
Isopentyl compounds
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