Tinyatoxin (TTX or TTN) is an analog of the neurotoxin

resiniferatoxin Resiniferatoxin (RTX) is a naturally occurring chemical found in resin spurge (''Euphorbia resinifera''), a cactus-like plant commonly found in Morocco, and in '' Euphorbia poissonii'' found in northern Nigeria.

. It occurs naturally in ''

Euphorbia poissonii ''Euphorbia poissonii'', also known as ''Euphorbia poissoni'' and, incorrectly, as ''Euphorbia poisoni'', is a highly irritant and toxic succulent member of the large and varied spurge family of plants.

''.''Euphorbia poissonii''
in BoDD – Botanical Dermatology Database It is a neurotoxin that acts via full agonism of the

vanilloid The vanilloids are compounds which possess a vanillyl group. They include vanillyl alcohol, vanillin, vanillic acid, acetovanillon, vanillylmandelic acid, homovanillic acid, capsaicin, etc. Isomers are the isovanilloids. : A number of vanilloi ...

receptors of sensory nerves. Tinyatoxin has a potential for pharmaceutical uses similar to uses of

capsaicin Capsaicin (8-methyl-''N''-vanillyl-6-nonenamide) ( or ) is an active component of chili peppers, which are plants belonging to the genus ''Capsicum''. It is a chemical irritant for mammals, including humans, and produces a sensation of burning ...

. Tinyatoxin is about one third as strong as

but is still an ultrapotent analogue of capsaicin, with a heat intensity estimate of 300 to 350 times that of capsaicin.

References

Plant toxins Terpenes and terpenoids Carboxylate esters Orthoesters Ion channel toxins Benzyl compounds {{organic-compound-stub