Timepidium bromide (
INN
Inns are generally establishments or buildings where travelers can seek lodging, and usually, food and drink. Inns are typically located in the country or along a highway. Before the advent of motorized transportation, they also provided accomm ...
) is an
anticholinergic
Anticholinergics (anticholinergic agents) are substances that block the action of the acetylcholine (ACh) neurotransmitter at synapses in the central nervous system, central and peripheral nervous system.
These agents inhibit the parasympatheti ...
. It is used in the symptomatic treatment of visceral spasms. It is also used to relieve pain associated with various gastrointestinal disorders.
The quaternary nitrogen prevents it from crossing the
blood brain barrier
Blood is a body fluid in the circulatory system of humans and other vertebrates that delivers necessary substances such as nutrients and oxygen to the cells, and transports metabolic waste products away from those same cells.
Blood is compo ...
, so it is peripherally acting with no central side effects.
The same compound ''sans'' the quaternary methyl group and the methoxy ether is called
tipepidine
Tipepidine (International Nonproprietary Name, INN; also known as tipepidine hibenzate (Japanese Accepted Name, JAN); brand names Asverin, Antupex, Asvelik, Asvex, Bitiodin, Cofdenin A, Hustel, Nodal, and Sotal) is a Organic compound#Synthetic co ...
.
References
Alkene derivatives
Bromides
Ethers
M1 receptor antagonists
M2 receptor antagonists
M3 receptor antagonists
M4 receptor antagonists
M5 receptor antagonists
Peripherally selective drugs
Piperidines
Quaternary ammonium compounds
Thiophenes
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