Tigliane is a
diterpene
Diterpenes are a class of chemical compounds composed of four isoprene units, often with the molecular formula C20H32. They are biosynthesized by plants, animals and fungi via the HMG-CoA reductase pathway, with geranylgeranyl pyrophosphate being ...
that forms the structural basis for some
natural chemical compounds such as
phorbol
Phorbol is a natural, plant-derived organic compound. It is a member of the tigliane family of diterpenes. Phorbol was first isolated in 1934 as the hydrolysis product of croton oil, which is derived from the seeds of the purging croton, '' Croto ...
.
[Qi-Run Li, Yung-Yi Cheng, Lei Zhao, Xiao-Lei Huang, Xiao-Gang Jiang, Ya-Dong Cui, Susan L. Morris-Natschke, Masuo Goto, Chin-Ho Chen, Kuo-Hsiung Lee, Dao-Feng Chen, Jian Zhang]
New phorbol ester derivatives as potent anti-HIV agents
''Bioorganic & Medicinal Chemistry Letters'', 50, 2021, ; ISSN 0960-894X.
See also
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Abietane
Abietane is a diterpene that forms the structural basis for a variety of natural chemical compounds such as abietic acid, carnosic acid, and ferruginol which are collectively known as abietanes or abietane diterpenes.
Abietanes are found in the ...
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Labdane
Labdane is a natural bicyclic diterpene. It forms the structural core for a wide variety of natural products collectively known as ''labdanes'' or ''labdane diterpenes''. The labdanes were so named because the first members of the class were ori ...
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Ingenane
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Phorbol esters
Phorbol esters are a class of chemical compounds found in a variety of plants, particularly in the families Euphorbiaceae and Thymelaeaceae. Chemically, they are ester
In chemistry, an ester is a compound derived from an oxoacid (organic or in ...
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Tigilanol tiglate
Tigilanol tiglate (USAN; ), sold under the brand name Stelfonta is a medication used to treat dogs with non-metastatic, skin-based (cutaneous) mast cell tumors (MCTs). The FDA is also approving Stelfonta to treat non-metastatic MCTs located under ...
References
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Diterpenes
Cyclopropanes
Cyclopentanes
Tetracyclic compounds