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A tic is a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups. American Psychiatric Association (2000)
DSM-IV-TR: Tourette's Disorder.
''Diagnostic and Statistical Manual of Mental Disorders'', 4th ed., text revision ( DSM-IV-TR), . Available at BehaveNet.com Retrieved on August 10, 2009.
Tics can be invisible to the observer, such as abdominal tensing or toe crunching. Common motor and phonic tics are, respectively, eye blinking and throat clearing. Tics must be distinguished from movements of disorders such as chorea,
dystonia Dystonia is a neurological hyperkinetic movement disorder in which sustained or repetitive muscle contractions result in twisting and repetitive movements or abnormal fixed postures. The movements may resemble a tremor. Dystonia is often inten ...
and myoclonus; the compulsions of obsessive–compulsive disorder (OCD) and seizure activity; and movements exhibited in stereotypic movement disorder or among autistic people (also known as stimming).


Classification

Tics are classified as either motor or phonic, and simple or complex.


Motor or phonic

Motor tics are movement-based tics affecting discrete muscle groups. Phonic tics are involuntary sounds produced by moving air through the nose, mouth, or throat. They may be alternately referred to as verbal tics or vocal tics, but most diagnosticians prefer the term ''phonic tics'' to reflect the notion that the vocal cords are not involved in all tics that produce sound.


Simple or complex

Simple motor tics are typically sudden, brief, meaningless movements that usually involve only one group of muscles, such as eye blinking, head jerking, or shoulder shrugging. Motor tics can be of an endless variety and may include such movements as hand clapping, neck stretching, mouth movements, head, arm or leg jerks, and facial grimacing. A simple phonic tic can be almost any sound or noise, with common vocal tics being throat clearing, sniffing, or grunting. Complex motor tics are typically more purposeful-appearing and of a longer nature. They may involve a cluster of movements and appear coordinated. Examples of complex motor tics are pulling at clothes, touching people, touching objects, echopraxia (repeating or imitating another person's actions) and copropraxia (involuntarily performing obscene or forbidden gestures). Complex phonic tics include echolalia (repeating words just spoken by someone else), palilalia (repeating one's own previously spoken words), lexilalia (repeating words after reading them), and coprolalia (the spontaneous utterance of socially objectionable or taboo words or phrases). Coprolalia is a highly publicized symptom of Tourette syndrome; however, only about 10% of TS patients exhibit coprolalia. Martino, et al have argued that tics may be considered physiological, or developmentally typical.


Characteristics

Tics are described as ''semi-voluntary'' or ''unvoluntary'', because they are not strictly ''involuntary''—they may be experienced as a ''voluntary'' response to a
premonitory urge A premonitory urge is a sensory phenomenon associated with Tourette syndrome and other tic disorders. Premonitory urges are "uncomfortable feelings or sensations preceding tics that usually are relieved by particularmovement". "Individuals ...
(a
sensory phenomena Sensory phenomena are general feelings, urges or bodily sensations. They are present in many conditions including autism spectrum disorders, epilepsy, neuropathy, obsessive–compulsive disorder, pain conditions, tardive syndromes, and tic disord ...
that is an inner sensation of mounting tension). A unique aspect of tics, relative to other movement disorders, is that they are suppressible yet irresistible; they are experienced as an irresistible urge that must eventually be expressed. Tics may increase as a result of stress, fatigue, boredom, or high-energy emotions, which can include negative emotions, such as anxiety, as well as positive emotions, such as excitement or anticipation. Relaxation may result in a tic increase (for instance, watching television or using a computer), while concentration on an absorbing activity often leads to a decrease in tics. Neurologist and writer Oliver Sacks described a physician with severe Tourette syndrome (Canadian Mort Doran, M.D., a pilot and surgeon in real life, although a pseudonym was used in the book), whose tics remitted almost completely while he was performing surgery. Immediately preceding tic onset, most individuals are aware of an urge that is similar to the need to yawn, sneeze, blink, or scratch an itch. Individuals describe the need to tic as a buildup of tension that they consciously choose to release, as if they "had to do it". Examples of this premonitory urge are the feeling of having something in one's throat or a localized discomfort in the shoulders, leading to the need to clear one's throat or shrug the shoulders. The actual tic may be felt as relieving this tension or sensation, similar to scratching an itch. Another example is blinking to relieve an uncomfortable sensation in the eye. Some people with tics may not be aware of the premonitory urge. Children may be less aware of the premonitory urge associated with tics than are adults, but their awareness tends to increase with maturity. Complex tics are rarely seen in the absence of simple tics. Tics "may be challenging to differentiate from compulsions", as in the case of
klazomania Klazomania (from the Greek κλάζω ("klazo")—to scream) refers to compulsive shouting; it has features resembling the complex tics such as echolalia, palilalia and coprolalia seen in tic disorders, but has been seen in people with encephalitis ...
(compulsive shouting).


Diagnosis

Tic disorders occur along a spectrum, ranging from mild (transient or chronic tics) to more severe; Tourette syndrome is the more severe expression of a spectrum of tic disorders, which are thought to be due to the same genetic vulnerability. Nevertheless, most cases of Tourette syndrome are not severe. Management for the spectrum of tic disorders is similar to the management of Tourette syndrome. Tic disorders are defined based on symptoms and duration.American Psychiatric Association (2013). ''Diagnostic and Statistical Manual of Mental Disorders'', 5th ed., pp. 81–85

/ref> The fifth edition of the ''Diagnostic and Statistical Manual of Mental Disorders'' ( DSM-5), published in May 2013, reclassified Tourette's and tic disorders as motor disorders listed in the neurodevelopmental disorder category, removed the word "stereotyped" from the definition of ''tic'' to better distinguish between
stereotypies A stereotypy (, or ) is a repetitive or ritualistic movement, posture, or utterance. Stereotypies may be simple movements such as body rocking, or complex, such as self-caressing, crossing and uncrossing of legs, and marching in place. They are ...
and tics, replaced transient tic disorder with provisional tic disorder, removed the criterion that tics must occur nearly every day, and removed the criterion that previously had excluded long tic-free periods (months) from counting towards the year needed to diagnose Tourette's or Persistent (Chronic) tic disorders.Neurodevelopmental disorders.
American Psychiatric Association. Retrieved on December 29, 2011.
"Highlights of changes from DSM-IV-TR to DSM-5" (PDF).
American Psychiatric Association. 2013. Retrieved on June 5, 2013.


Differential diagnosis

Dystonia Dystonia is a neurological hyperkinetic movement disorder in which sustained or repetitive muscle contractions result in twisting and repetitive movements or abnormal fixed postures. The movements may resemble a tremor. Dystonia is often inten ...
s, paroxysmal dyskinesias, chorea, other genetic conditions, and secondary causes of tics should be ruled out in the
differential diagnosis In healthcare, a differential diagnosis (abbreviated DDx) is a method of analysis of a patient's history and physical examination to arrive at the correct diagnosis. It involves distinguishing a particular disease or condition from others that p ...
. Conditions besides Tourette syndrome that may manifest tics or stereotyped movements include developmental disorders, autism spectrum disorders, and stereotypic movement disorder;Freeman, RD.
Tourette's Syndrome: minimizing confusion
Roger Freeman, MD, blog. Retrieved on February 8, 2006.
Sydenham's chorea Sydenham's chorea, also known as rheumatic chorea, is a disorder characterized by rapid, uncoordinated jerking movements primarily affecting the face, hands and feet. Sydenham's chorea is an autoimmune disease that results from childhood infecti ...
; idiopathic dystonia; and genetic conditions such as Huntington's disease, neuroacanthocytosis, pantothenate kinase-associated neurodegeneration, Duchenne muscular dystrophy, Wilson's disease, and
tuberous sclerosis Tuberous sclerosis complex (TSC) is a rare multisystem autosomal dominant genetic disease that causes non-cancerous tumours to grow in the brain and on other vital organs such as the kidneys, heart, liver, eyes, lungs and skin. A combination ...
. Other possibilities include chromosomal disorders such as Down syndrome, Klinefelter syndrome, XYY syndrome, and
fragile X syndrome Fragile X syndrome (FXS) is a genetic disorder characterized by mild-to-moderate intellectual disability. The average IQ in males with FXS is under 55, while about two thirds of affected females are intellectually disabled. Physical features may ...
. Acquired causes of tics include drug-induced tics, head trauma,
encephalitis Encephalitis is inflammation of the brain. The severity can be variable with symptoms including reduction or alteration in consciousness, headache, fever, confusion, a stiff neck, and vomiting. Complications may include seizures, hallucinations, ...
,
stroke A stroke is a medical condition in which poor blood flow to the brain causes cell death. There are two main types of stroke: ischemic, due to lack of blood flow, and hemorrhagic, due to bleeding. Both cause parts of the brain to stop functionin ...
, and carbon monoxide poisoning. Most of these conditions are rarer than tic disorders, and a thorough history and examination may be enough to rule them out, without medical or screening tests. Although tic disorders are commonly considered to be childhood syndromes, tics occasionally develop during adulthood; adult-onset tics often have a secondary cause. Tics that begin after the age of 18 are not diagnosed as Tourette's syndrome, but may be diagnosed as an "other specified" or "unspecified" tic disorder. Tests may be ordered as necessary to rule out other conditions: For example, when diagnostic confusion between tics and seizure activity exists, an EEG may be ordered, or symptoms may indicate that an MRI is needed to rule out brain abnormalities. TSH levels can be measured to rule out
hypothyroidism Hypothyroidism (also called ''underactive thyroid'', ''low thyroid'' or ''hypothyreosis'') is a disorder of the endocrine system in which the thyroid gland does not produce enough thyroid hormone. It can cause a number of symptoms, such as po ...
, which can be a cause of tics. Brain imaging studies are not usually warranted. In teenagers and adults presenting with a sudden onset of tics and other behavioral symptoms, a urine drug screen for cocaine and
stimulants Stimulants (also often referred to as psychostimulants or colloquially as uppers) is an overarching term that covers many drugs including those that increase activity of the central nervous system and the body, drugs that are pleasurable and inv ...
might be necessary. If a family history of liver disease is present, serum copper and ceruloplasmin levels can rule out Wilson's disease.Bagheri, Kerbeshian & Burd (1999). Individuals with obsessive–compulsive disorder (OCD) may present with features typically associated with a tic disorder, such as compulsions that may resemble motor tics. "Tic-related OCD" is hypothesized to be a subgroup of OCD, distinguished from non-tic-related OCD by the content and type of obsessions and compulsions; individuals with tic-related OCD have more intrusive thoughts, and exhibit more hoarding and counting rituals than individuals with non-tic-related OCD. Tics must also be distinguished from
fasciculation A fasciculation, or muscle twitch, is a spontaneous, involuntary muscle contraction and relaxation, involving fine muscle fibers. They are common, with as many as 70% of people experiencing them. They can be benign, or associated with more serio ...
s. Small twitches of the upper or lower eyelid, for example, are not tics, because they do not involve a whole muscle, rather are twitches of a few muscle fibre bundles, that are not suppressible.


See also

* Yale Global Tic Severity Scale, a psychological measure designed to identify symptoms of disorders relating to attention and impulsivity, such as tic disorder, Tourette’s syndrome, and obsessive-compulsive disorder, in children and adolescents between ages 6 to 17.


Notes


External links

* Black, Kevin J
Tourette syndrome and other tic disorders. eMedicine 2001-2008.
* Robertson, William C
Tourette Syndrome and Other Tic Disorders. eMedicine 2009-2019.
* Evidente, GH
"Is it a tic or Tourette's? Clues for differentiating simple from more complex tic disorders."
''PostGraduate Medicine Online''. October 2000 108:5. * * {{Obsessive–compulsive disorder Habits Articles containing video clips