Thrombopoietic agents are drugs that induce the growth and maturation of
megakaryocyte
A megakaryocyte (''mega-'' + '' karyo-'' + '' -cyte'', "large-nucleus cell") is a large bone marrow cell with a lobated nucleus responsible for the production of blood thrombocytes (platelets), which are necessary for normal blood clotting. In hum ...
s. Some of them are currently in clinical use:
romiplostim
Romiplostim, sold under the brand name Nplate among others, is a fusion protein analog of thrombopoietin, a hormone that regulates platelet production.
Indications and Marketing
The drug was developed by Amgen through a restricted usage program ...
,
Romiplostim
/ref> eltrombopag
Eltrombopag, sold under the brand name Promacta among others, is a medication used to treat thrombocytopenia (abnormally low platelet counts) and severe aplastic anemia. Eltrombopag is sold under the brand name Revolade outside the US and is mar ...
, oprelvekin (a recombinant interleukin 11
Interleukin 11 (IL-11) is a protein that in humans is encoded by the ''IL11'' gene.
IL-11 is a cytokine and first isolated in 1990 from bone marrow-derived fibrocyte-like stromal cells. It was initially thought to be important for hematopoiesis ...
) and thrombopoietin
Thrombopoietin (THPO) also known as megakaryocyte growth and development factor (MGDF) is a protein that in humans is encoded by the ''THPO'' gene.
Thrombopoietin is a glycoprotein hormone produced by the liver and kidney which regulates the pro ...
. Several others are under clinical investigation such as lusutrombopag and avatrombopag.
References
Drugs
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