''Thottopalayam thottimvirus'', formerly ''Thottapalayam virus'', (TMPV) is single-stranded, enveloped, negative-sense RNA virus species of the genus '' Thottimvirus'' in the ''

Bunyavirales ''Bunyavirales'' is an order of segmented negative-strand RNA viruses with mainly tripartite genomes. Member viruses infect arthropods, plants, protozoans, and vertebrates. It is the only order in the class ''Ellioviricetes''. The name ''Bunyavir ...

'' order. It is the first hantavirus to be isolated from a

shrew Shrews (family Soricidae) are small mole-like mammals classified in the order Eulipotyphla. True shrews are not to be confused with treeshrews, otter shrews, elephant shrews, West Indies shrews, or marsupial shrews, which belong to different fa ...

. It was discovered in

India India, officially the Republic of India (Hindi: ), is a country in South Asia. It is the seventh-largest country by area, the second-most populous country, and the most populous democracy in the world. Bounded by the Indian Ocean on the so ...

in 1964.

Natural reservoir

TPMV was first isolated from an Asian house shrew (''

Suncus murinus The Asian house shrew (''Suncus murinus'') is a shrew species native to South and Southeast Asia that has been listed as Least Concern on the IUCN Red List since 2008 because of its large population and wide distribution. It has been introduced i ...

'') in India in 1964. It is part of a group of hantaviruses which are hosted by shrews instead of rodents. These shrew-borne ''thottimviruses'' are not known to cause any known disease in humans, unlike the similar and related ''orthohantaviruses'' including

Andes The Andes, Andes Mountains or Andean Mountains (; ) are the longest continental mountain range in the world, forming a continuous highland along the western edge of South America. The range is long, wide (widest between 18°S – 20°S ...

and Hantaan viruses, which cause lethal hemorrhagic fevers. TPMV was first isolated in Asian house shrews in

Wenzhou Wenzhou (pronounced ; Wenzhounese: Yuziou �y33–11 tɕiɤu33–32 ), historically known as Wenchow is a prefecture-level city in southeastern Zhejiang province in the People's Republic of China. Wenzhou is located at the extreme south east o ...

Zhejiang Zhejiang ( or , ; , also romanized as Chekiang) is an eastern, coastal province of the People's Republic of China. Its capital and largest city is Hangzhou, and other notable cities include Ningbo and Wenzhou. Zhejiang is bordered by Jiang ...

province,

China China, officially the People's Republic of China (PRC), is a country in East Asia. It is the world's most populous country, with a population exceeding 1.4 billion, slightly ahead of India. China spans the equivalent of five time zones and ...

Virology

Phylogenetic analysis has shown that Thottapalayam virus, and its closely related strains, is unique and forms a distinct lineage, unrelated to other hantaviruses. The closest hantavirus to TMPV is

Imjin virus ''Imjin thottimvirus'' (MJNV) is a single-stranded, enveloped, negative-sense RNA virus of the orthohantavirus genus in the Bunyavirales order. It is a newly identified hantavirus isolated from the lung tissues of Ussuri white-toothed shrews of ...

which demonstrates corresponding nucleotide sequences to TPMV as does

Tanganya virus Tanganya virus (TGNV) is an enveloped, single-stranded, negative-sense RNA virus, possibly of the genus orthohantavirus in the Bunyavirales order. It is the second indigenous Murinae The Old World rats and mice, part of the subfamily Muri ...

.Wen-Ping Guo, Xian-Dan Lin, Wen Wang, Xiao-He Zhang, Yi Chen, Jian-Hai Cao, Qing-Xiang Ni, Wang-Cang Li, Ming-Hui Li, Alexander Plyusnin,

Yong-Zhen Zhang Zhang Yongzhen (), also known as Yong-Zhen Zhang, is a Chinese virologist known for his work relating to the COVID-19 pandemic. A professor at Fudan University, Zhang has discovered numerous RNA viruses and created a network of labs dedicated t ...

. A new subtype of Thottapalayam virus carried by the Asian house shrew (Suncus murinus) in China. Infection, genetics and evolution: journal of molecular epidemiology and evolutionary genetics in infectious diseases (Impact Factor: 3.22). 07/2011; 11(8):1862–7.

References

External links

CDC's Hantavirus Technical Information Index page

Virus Pathogen Database and Analysis Resource (ViPR): Bunyaviridae
{{Taxonbar, from1=Q57756478, from2=Q29002564, from3=Q16994513, from4=Q24764393 Viral diseases Hantaviridae Hemorrhagic fevers Rodent-carried diseases

Natural reservoir

Virology

See also

References

External links