Thomas Walter Warnes (born 1938) was an English gastroenterologist. He graduated from the University of Manchester in 1962 and took the MD in 1975. He had a particular interest in liver disease. The major contributions in his M.D Thesis included 1) The development of new techniques to separate and identify

Alkaline phosphatase The enzyme alkaline phosphatase (EC 3.1.3.1, alkaline phosphomonoesterase; phosphomonoesterase; glycerophosphatase; alkaline phosphohydrolase; alkaline phenyl phosphatase; orthophosphoric-monoester phosphohydrolase (alkaline optimum), systematic ...

(ALP)

isoenzymes In biochemistry, isozymes (also known as isoenzymes or more generally as multiple forms of enzymes) are enzymes that differ in amino acid sequence but catalyze the same chemical reaction. Isozymes usually have different kinetic parameters (e.g. dif ...

in blood and duodenal juice; 2) The first demonstration of a hormonal action on an enzyme from the same tissue (small intestine); 3) The first demonstration of an entero-hepatic circulation of a glycoprotein enzyme. He became Senior Physician in the University Department of Gastroenterology at Manchester Royal Infirmary where he founded the Liver Unit. He was president of the North of England Gastroenterology Society; Deputy Director of

The British Liver Trust British Liver Trust is a charitable organisation in The United Kingdom which has a focus in the health of the liver. Based in the town of Winchester, the Trust is made up of over 20 employed members of staff who are supplemented by voluntary wo ...

and Visiting Professor in the Department of Biomolecular Sciences at the University of Manchester Institute of Science and Technology (UMIST). Over his career, he contributed to numerous publications on hepatic fibrosis; Oxidant stress in chronic liver disease;

Primary biliary cirrhosis Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune disease of the liver. It results from a slow, progressive destruction of the small bile ducts of the liver, causing bile and other toxins to build ...

(PBC);

Portal hypertension Portal hypertension is abnormally increased portal venous pressure – blood pressure in the portal vein and its branches, that drain from most of the intestine to the liver. Portal hypertension is defined as a hepatic venous pressure gradient gr ...

; Development of new drug treatments for chronic liver disease (incl. the first trial of colchicine in PBC);

isoenzymes; Hepatitis B & C;

Tumour marker A tumor marker is a biomarker found in blood, urine, or body tissues that can be elevated by the presence of one or more types of cancer. There are many different tumor markers, each indicative of a particular disease process, and they are used in ...

s of primary liver cancer; Occupational liver disease. He published in prestigious peer reviewed journals including: Journal of Hepatology;

Hepatology (journal) ''Hepatology'' is a peer-reviewed medical journal of hepatology. It is published monthly by John Wiley & Sons on behalf of the American Association for the Study of Liver Diseases. The journal was established in 1981 and the editor-in-chief is D ...

;

Gut (journal) ''Gut'' is a monthly peer reviewed medical journal on gastroenterology and hepatology. It is the journal of the British Society of Gastroenterology and is published by BMJ. , the editor-in-chief is Emad El-Omar. ''Gut'' was established in 1960 an ...

; The American Journal of Human Genetics; The

European Journal of Gastroenterology and Hepatology The ''European Journal of Gastroenterology & Hepatology'' is a peer reviewed medical journal covering the fields of gastroenterology and hepatology. It was established in 1989 and is published by Lippincott Williams & Wilkins. The editors-in-chief ...

; The Lancet;

British Medical Journal ''The BMJ'' is a weekly peer-reviewed medical trade journal, published by the trade union the British Medical Association (BMA). ''The BMJ'' has editorial freedom from the BMA. It is one of the world's oldest general medical journals. Origi ...

; Gastroenterology (journal); The New England Journal of Medicine,...).

References

20th-century English medical doctors People educated at William Hulme's Grammar School 1938 births British gastroenterologists Fellows of the Royal College of Physicians Living people {{UK-med-bio-stub