Thomas A. Reh

Ph.D. A Doctor of Philosophy (PhD, Ph.D., or DPhil; Latin: or ') is the most common degree at the highest academic level awarded following a course of study. PhDs are awarded for programs across the whole breadth of academic fields. Because it is a ...

is an American scientist and author. He received his

B.Sc. A Bachelor of Science (BS, BSc, SB, or ScB; from the Latin ') is a bachelor's degree awarded for programs that generally last three to five years. The first university to admit a student to the degree of Bachelor of Science was the University of ...

biochemistry Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and ...

from the

University of Illinois at Urbana-Champaign The University of Illinois Urbana-Champaign (U of I, Illinois, University of Illinois, or UIUC) is a public land-grant research university in Illinois in the twin cities of Champaign and Urbana. It is the flagship institution of the Univ ...

in 1977 and his Ph.D. in

neuroscience Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions and disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, development ...

from the

University of Wisconsin–Madison A university () is an educational institution, institution of higher education, higher (or Tertiary education, tertiary) education and research which awards academic degrees in several Discipline (academia), academic disciplines. Universities ty ...

in 1981. He went on to postdoctoral studies at

Princeton University Princeton University is a private university, private research university in Princeton, New Jersey. Founded in 1746 in Elizabeth, New Jersey, Elizabeth as the College of New Jersey, Princeton is the List of Colonial Colleges, fourth-oldest ins ...

in the lab of

Martha Constantine-Paton Martha Constantine-Paton is a neuroscientist at the Massachusetts Institute of Technology. She is a member of the McGovern Institute for Brain Research and a professor in the Department of Brain and Cognitive Sciences. Overview Prior to joinin ...

. He is currently professor of biological structure and former director of the Neurobiology and Behavior Program at the

University of Washington The University of Washington (UW, simply Washington, or informally U-Dub) is a public research university in Seattle, Washington. Founded in 1861, Washington is one of the oldest universities on the West Coast; it was established in Seattle a ...

. The overall goal of Reh’s research is to understand the cell and

molecular biology Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physi ...

regeneration Regeneration may refer to: Science and technology * Regeneration (biology), the ability to recreate lost or damaged cells, tissues, organs and limbs * Regeneration (ecology), the ability of ecosystems to regenerate biomass, using photosynthesis ...

in the

eye Eyes are organs of the visual system. They provide living organisms with vision, the ability to receive and process visual detail, as well as enabling several photo response functions that are independent of vision. Eyes detect light and conv ...

. He has worked at the interface between development and regeneration, focusing on the

retina The retina (from la, rete "net") is the innermost, light-sensitive layer of tissue of the eye of most vertebrates and some molluscs. The optics of the eye create a focused two-dimensional image of the visual world on the retina, which then ...

. The lab is currently divided into a team that studies retinal development and a team that studies retinal regeneration, with the goal of applying the principles learned from developmental biology to design rationale strategies for promoting retinal regeneration in the adult mammalian retina. His research has been funded through numerous grants from the

National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...

(NIH) and many private foundations, and he has served on several national and international grant review panels, including NIH study sections, and is currently a member of the Scientific Advisory Board of the Foundation Fighting Blindness and of a start-up biotechnology company, Acucela. He has received several awards for his work, including the AHFMR and Sloan Scholar awards. He has published over 100 journal articles, reviews and books, nearly all in the field of retinal regeneration and development.

Publications

Microglia suppress Ascl1-induced retinal regeneration in mice. Todd, L., Finkbeiner, C., Wong, C.K., Hooper, M.J. Reh, T.A. Cell Reports. 2020 Dec 15; 33 (11): 108507. PMID 33326790

Developmental changes in the accessible chromatin, transcriptome and Ascl1-binding correlate with the loss in Müller Glial regenerative potential. Vandenbosch, L.V., Wohl, S.G, Wilken, M.S., Hooper, M.J., Finkbeiner, C., Cox, K., Chipman, L. Reh. T.A. Scientific Reports. 2020 Aug 12;10(1):13615. doi: 10.1038/s41598-020-70334-1.

Single-Cell Transcriptomic Comparison of Human Fetal Retina, hPSC-Derived Retinal Organoids, and Long-Term Retinal Cultures. Sridhar A, Hoshino A, Finkbeiner CR, Chitsazan A, Dai L, Haugan AK, Eschenbacher KM, Jackson DL, Trapnell C, Bermingham-McDonogh O, Glass I, Reh TA. Cell Rep. 2020 Feb 4;30(5):1644-1659.e4. doi: 10.1016/j.celrep.2020.01.007. PMID 32023475

STAT Signaling Modifies Ascl1 Chromatin Binding and Limits Neural Regeneration from Muller Glia in Adult Mouse Retina. Jorstad NL, Wilken MS, Todd L, Finkbeiner C, Nakamura P, Radulovich N, Hooper MJ, Chitsazan A, Wilkerson BA, Rieke F, Reh TA. Cell Rep. 2020 Feb 18;30(7):2195-2208.e5. doi: 10.1016/j.celrep.2020.01.075. PMID 32075759

MicroRNAs miR-25, let-7 and miR-124 regulate the neurogenic potential of Müller glia in mice.Wohl SG, Hooper MJ, Reh TA.Development. 2019 Aug 5. pii: dev.179556. doi: 10.1242/dev.179556. [Epub ahead of print
/nowiki>PMID 31383796 [PubMed - as supplied by publisher]Similar articles]
Synchrony and asynchrony between an epigenetic clock and developmental timing. Hoshino A, Horvath S, Sridhar A, Chitsazan A, Reh TA.Sci Rep. 2019 Mar 6;9(1):3770. doi: 10.1038/s41598-019-39919-3.PMID 30842553 [PubMed - in process
/nowiki> Free PMC Article Similar articles]

Textbooks

* Sanes, Reh, Harris (2005). Development of the Nervous System, 2nd edition. Academic Press;

References

External links

Reh Lab

Neurobiology and Behavior at the University of Washington

Biological Structure at the University of Washington
{{DEFAULTSORT:Reh, Thomas American biochemists University of Wisconsin–Madison alumni Living people Year of birth missing (living people)