Thiorphan is the active
metabolite of the
antidiarrheal
An anti-diarrhoeal drug (or anti-diarrheal drug in American English) is any medication which provides symptomatic relief for diarrhoea.
Types
* Electrolyte solutions, while not true antidiarrhoeals, are used to replace lost fluids and salts in ac ...
racecadotril
Racecadotril, also known as acetorphan, is an antidiarrheal medication which acts as a peripheral enkephalinase inhibitor. Unlike other opioid medications used to treat diarrhea, which reduce intestinal motility, racecadotril has an antisecret ...
(acetorphan).
It prevents the degradation of
endogenous enkephalin
An enkephalin is a pentapeptide involved in regulating nociception in the body. The enkephalins are termed endogenous ligands, as they are internally derived and bind to the body's opioid receptors. Discovered in 1975, two forms of enkephali ...
s by acting as an
enkephalinase inhibitor.
References
Enkephalinase inhibitors
Antidiarrhoeals
Amino acid derivatives
Thiols
Carboxamides
Propionamides
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