A thienotriazolodiazepine is a heterocyclic compound containing a
diazepine
Diazepine is a seven-membered heterocyclic compound with two nitrogen atoms (e.g., in ring positions 1 and 2).
Types include:
* 1,2-diazepine
* 1,3-diazepine
* 1,4-diazepine
** Benzodiazepines
Benzodiazepines (BZD, BDZ, BZs), sometimes cal ...
ring fused to
thiophene
Thiophene is a heterocyclic compound with the formula C4H4S. Consisting of a planar five-membered ring, it is aromatic as indicated by its extensive substitution reactions. It is a colorless liquid with a benzene-like odor. In most of its react ...
and
triazole
A triazole is a heterocyclic compound featuring a five-membered ring of two carbon atoms and three nitrogen atoms with molecular formula C2H3N3. Triazoles exhibit substantial isomerism, depending on the positioning of the nitrogen atoms within t ...
rings. Thienotriazolodiazepine forms the central core of several pharmaceutical drugs including:
*
Brotizolam
*
Ciclotizolam
*
Deschloroetizolam
*
Etizolam
Etizolam (marketed under many brand names) is a thienodiazepine derivative which is a benzodiazepine analog. The etizolam molecule differs from a benzodiazepine in that the benzene ring has been replaced by a thiophene ring and triazole ring ha ...
*
Fluclotizolam
*
Metizolam
Thienotriazolodiazepines interact with the
benzodiazepine receptor site, they typically have similar effects as 1,4-
benzodiazepines (such as
diazepam
Diazepam, first marketed as Valium, is a medicine of the benzodiazepine family that acts as an anxiolytic. It is commonly used to treat a range of conditions, including anxiety, seizures, alcohol withdrawal syndrome, muscle spasms, insomnia, ...
) and triazolobenzodiazepines (such as
alprazolam
Alprazolam, sold under the brand name Xanax, among others, is a fast-acting, potent tranquilizer of medium duration in the triazolobenzodiazepine (TBZD) class, which are benzodiazepines (BZDs) fused with a triazole ring. It is most commonly u ...
).
Thienotriazolodiazepines that are not
GABAA receptor positive allosteric modulators include:
*
Israpafant
*
JQ1
References
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