Thelaziasis

Thelaziasis is the term for infestation with parasitic nematodes of the genus ''Thelazia''. The adults of all ''Thelazia'' species discovered so far inhabit the eyes and associated tissues (such as eyelids, tear ducts, etc.) of various mammal and bird hosts, including humans. ''Thelazia'' nematodes are often referred to as "eyeworms".

Signs and symptoms

In animal and human hosts, infestation by ''Thelazia'' may be asymptomatic, though it frequently causes watery eyes ( epiphora), conjunctivitis, corneal opacity, or corneal ulcers (ulcerative keratitis). Infested humans have also reported "foreign body sensation"the feeling that something is in the eye.

Cause

Life cycle

In the uterus of the adult female, the embryos develop into first-stage larvae (L1), which remain in the eggshell (sheath). The female deposits these sheathed larvae in the tears of the mammal or bird definitive host, and the larvae are ingested by tear-feeding flies. In the fly, the larvae "hatch" (exsheath), penetrate the gut wall, and migrate to either the fat body, testes or egg follicles (depending on the species). There they develop into third-stage larvae (L3), which migrate to the head of the fly. The infective L3 larvae wiggle out of the straw-like feeding apparatus of the fly when it feeds on the tears of another mammal or bird host. The L3 larvae develop into adults in the eye or surrounding tissues of the host, where they may live for over one year.

In the definitive host, ''Thelazia'' have been found in various tissues of the orbit (or socket) of the eye, including within the eyelids, in the tear glands, tear ducts, or the so-called "third eyelid" (nictitating membrane) or in the eyeball itself.

Hosts and geographic range

While a few dozen species of ''Thelazia'' have been described in the literature, only three have been reported to infest humans, and only seven are commonly reported in veterinary contexts. The remaining species are occasionally found in birds or wild mammals.

In humans, dogs and cats, thelaziasis cases due to ''Thelazia callipaeda'' (Asia, Europe), and occasionally ''T. californiensis'' and ''T. gulosa'' (western North America), have been reported.

Horses are infested by ''T. lacrymalis'' (worldwide) and, less frequently, by ''T. rhodesii'' (Africa, Asia, Europe).

In cattle, ''T. gulosa'' (Asia, Europe, North America), ''T. rhodesii'' (Africa, Asia, Europe) and ''T. skrjabini'' (Europe, North America) are the primary species of concern.

In camels, ''T. leesei'' infestations have been reported from the Post-Soviet states and India.

The intermediate hosts of several ''Thelazia'' species are known, and in each case they are tear-feeding flies of the genera ''Musca'' (family Muscidae), ''Phortica'' (family Drosophilidae), or ''Fannia'' (family Fanniidae).

Diagnosis

Diagnosis involves simply examining the eyes and nearby tissues for the worms. Adult ''Thelazia'' are very active, one author described ''T. californiensis'' as a "short lively piece of nylon fishing line about 10 mm long."

Treatment

Because they live so close to the outside of the body, ''Thelazia'' is one of the few nematode infections which can be treated topically.

Topical treatment of livestock, dogs and cats with organophosphates (such as ecothiopate iodide or isofluorophate) and systemic treatment with anthelmintics (such as ivermectin, levamisole, and doramectin) are recommended by the Merck Veterinary Manual. Other sources have reported positive results treating dogs with moxidectin, imidacloprid, or milbemycin oxime.

For the treatment of human cases, removal of the worm is suggested. Topical treatment with cocaine or thiabendazole have also been reported to kill the worms in human cases. Because most, if not all, species of ''Thelazia'' are spread by flies, sanitary practices which reduce the presence of flies will also reduce the spread of thelaziasis.

In canines, prevention against canine thelaziosis by monthly administrations of a combination of milbemycin oxime and afoxolaner (NexGard Spectra) has been found effective.

Prevalence

By one author's count, 257 human cases of ''Thelazia callipaeda'' had been reported worldwide by the year 2000, though thelaziasis is still considered to be a rare disease.

Various livestock and wildlife surveys suggest that thelaziasis is quite common among animals.

*A slaughterhouse survey in Canada found that about one-third (32%) of cattle over an eight-month period were infested with eyeworms.
*A survey of horses in Kentucky revealed a 42% rate of infestation with ''Thelazia lacrymalis''.
*In Wyoming and Utah, a survey of hunter-harvested mule deer found 15% to be infested by ''Thelazia californiensis''.
*A survey of various sites in Italy found 23-60% of dogs, 5% of foxes and 4 out of 4 cats to be infested with ''Thelazia callipaeda''.
*In a study of dogs living in western Spain, 39.9% of the dogs were found to have ''Thelazia callipaeda'' worms living in their eyes.

References

External links

{{Helminthiases

Bovine diseases
Cat diseases
Dog diseases
Helminthiases
Spirurida
Veterinary helminthology