Tetrahydroharman(e), also known as 1-methyl-1,2,3,4-tetrahydro-β-carboline, is a general name for one of two isomers:
# (1S)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido
,4-bndole
# Calligonine ((1R)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido
,4-bndole)
Calligonine is a major alkaloid constituent of the roots of ''Calligonum minimum'' and the bark of ''
Elaeagnus angustifolia
''Elaeagnus angustifolia'', commonly called Russian olive, silver berry, oleaster, or wild olive, is a species of ''Elaeagnus'', native to western and central Asia, Iran, from southern Russia and Kazakhstan to Turkey, parts of Pakistan and parts of ...
''. When taken internally, it has the effect of substantially lowering blood pressure for an extended period of time, similar to
reserpine
Reserpine is a drug that is used for the treatment of high blood pressure, usually in combination with a thiazide diuretic or vasodilator. Large clinical trials have shown that combined treatment with reserpine plus a thiazide diuretic reduces m ...
.
References
Landolt-Börnstein*
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See also
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Peganum harmala
''Peganum harmala'', commonly called wild rue, Syrian rue, African rue, esfand or espand,Mahmoud OmidsalaEsfand: a common weed found in Persia, Central Asia, and the adjacent areasEncyclopedia Iranica Vol. VIII, Fasc. 6, pp. 583–584. Originall ...
*
Harmala alkaloid
Several alkaloids that function as monoamine oxidase inhibitors (MAOIs) are found in the seeds of ''Peganum harmala'' (also known as ''Harmal'' or ''Syrian Rue''), as well as tobacco leaves including harmine, harmaline, and harmalol, which are m ...
Tryptamine alkaloids
beta-Carbolines
{{Alkaloid-stub