In
enzymology
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
, a terephthalate 1,2-dioxygenase () is an
enzyme that
catalyzes
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...
the
chemical reaction
:terephthalate + NADH + H
+ + O
2 (1R,6S)-dihydroxycyclohexa-2,4-diene-1,4-dicarboxylate + NAD
+
The 4
substrates of this enzyme are
terephthalate,
NADH,
H+, and
O2, whereas its two
products are
(1R,6S)-dihydroxycyclohexa-2,4-diene-1,4-dicarboxylate and
NAD+.
This enzyme belongs to the family of
oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of two atoms o oxygen into the other donor. The
systematic name of this enzyme class is benzene-1,4-dicarboxylate,NADH:oxygen oxidoreductase (1,2-hydroxylating). Other names in common use include benzene-1,4-dicarboxylate 1,2-dioxygenase, and 1,4-dicarboxybenzoate 1,2-dioxygenase. This enzyme participates in
2,4-dichlorobenzoate degradation.
References
*
EC 1.14.12
NADPH-dependent enzymes
NADH-dependent enzymes
Enzymes of unknown structure
{{1.14-enzyme-stub