Tercica, Inc., was a biopharmaceutical company based in
Brisbane, California
Brisbane (pron. , unlike Brisbane, Queensland, Australia) is a small city located in California in the northern part of San Mateo County on the lower slopes of San Bruno Mountain. It is located on the southern border of San Francisco, on the ...
, United States. It developed
Increlex
Mecasermin, sold under the brand name Increlex, also known as recombinant human insulin-like growth factor-1 (rhIGF-1), is a recombinant form of human insulin-like growth factor 1 (IGF-I) which is used in the long-term treatment of growth failur ...
(mecasermin
DNA origininjection), also known as recombinant human Insulin-like Growth Factor-1 (
rhIGF-1). Tercica applied to the
Food and Drug Administration
The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is respon ...
(FDA) for approval of Increlex as a long-term therapy for growth failure in children with severe primary IGF-1 deficiency (
Primary IGFD), which is characterized by growth failure, and as a treatment for children with growth hormone (GH) gene deletion who have developed neutralizing antibodies to growth hormone.
Tercica licensed rights to develop, manufacture, and market Increlex from
Genentech
Genentech, Inc., is an American biotechnology corporation headquartered in South San Francisco, California. It became an independent subsidiary of Roche in 2009. Genentech Research and Early Development operates as an independent center within R ...
, Inc. Increlex conducted Phase III clinical trials to evaluate the safety and efficacy of Increlex in children with
Primary IGFD.
In 2007, a case between Insmed and Tercica was settled when the jury found that Insmed infringed patents licensed to Tercica for Increlex. In the settlement, Insmed agreed to stop selling Iplex in the United States as a treatment for growth deficiencies and to withdraw an application to have the drug approved for such use in Europe.
In 2008, the
Ipsen Group
Ipsen is a French biopharmaceutical company headquartered in Paris, France, with a focus on transformative medicines in three therapeutic areas: oncology, rare disease and neuroscience. Ipsen is one of the world’s top 15 biopharmaceutical com ...
acquired Tercica and changed its name to Ipsen Biopharmaceuticals, Inc.
See also
*
Human growth hormone (HGH)
*
IGF-1
Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a hormone similar in molecular structure to insulin which plays an important role in childhood growth, and has anabolic effects in adults.
IGF-1 is a protein that in humans is ...
References
External links
Ipsen Biopharmaceuticalswebsite
Companies formerly listed on the Nasdaq
Biotechnology companies of the United States
Companies based in San Mateo County, California
Brisbane, California
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