Taurochenodeoxycholic acid is a
bile acid
Bile acids are steroid acids found predominantly in the bile of mammals and other vertebrates. Diverse bile acids are synthesized in the liver. Bile acids are conjugated with taurine or glycine residues to give anions called bile salts.
Primary b ...
formed in the liver of most species, including humans, by conjugation of
chenodeoxycholic acid
Chenodeoxycholic acid (CDCA; also known as chenodesoxycholic acid, chenocholic acid and 3α,7α-dihydroxy-5β-cholan-24-oic acid) is a bile acid. Salts of this carboxylic acid are called chenodeoxycholates. Chenodeoxycholic acid is one of the mai ...
with
taurine
Taurine (), or 2-aminoethanesulfonic acid, is an organic compound that is widely distributed in animal tissues. It is a major constituent of bile and can be found in the large intestine, and accounts for up to 0.1% of total human body weight. I ...
.
It is secreted into
bile
Bile (from Latin ''bilis''), or gall, is a dark-green-to-yellowish-brown fluid produced by the liver of most vertebrates that aids the digestion of lipids in the small intestine. In humans, bile is produced continuously by the liver (liver bile ...
and then into intestine.
It is usually ionized at physiologic pH, although it can be crystallized as the sodium salt.
It acts as detergent to solubilize fats in the small intestine and is itself absorbed by active transport in the terminal
ileum
The ileum () is the final section of the small intestine in most higher vertebrates, including mammals, reptiles, and birds. In fish, the divisions of the small intestine are not as clear and the terms posterior intestine or distal intestine ma ...
.
It is used as a
cholagogue A cholagogue is a substance that is purported by humoral practitioners to encourage the discharge of bile from the system, purging it downward. Deployment is no longer recommended because the biliary purge, like the traditional kidney purge, can c ...
and
choleretic
Choleretics are substances that increase the volume of secretion of bile from the liver
The liver is a major organ only found in vertebrates which performs many essential biological functions such as detoxification of the organism, and the sy ...
.
See also
*
Tauroursodeoxycholic acid
Ursodoxicoltaurine is the international nonproprietary name (INN) for the pharmaceutical form of tauroursodeoxycholic acid (TUDCA). It is also known as taurursodiol. Tauroursodeoxycholic acid is a naturally occurring hydrophilic bile acid which ...
, an
epimer
In stereochemistry, an epimer is one of a pair of diastereomers. The two epimers have opposite configuration at only one stereogenic center out of at least two. All other stereogenic centers in the molecules are the same in each. Epimerization i ...
* See article about
Taurodeoxycholic acid
Taurodeoxycholic acid is a bile acid. This compound is a closely related isomer of Taurochenodeoxycholic acid and Tauroursodeoxycholic acid sharing the exact molecular formula and molecular weight.
Mass Spectrometry Interference with PFOS
Bens ...
as an interferent in
Perfluorooctanesulfonic acid
Perfluorooctanesulfonic acid (PFOS) (conjugate base perfluorooctanesulfonate) is a chemical compound having an eight-carbon fluorocarbon chain and a sulfonic acid functional group and thus a perfluorosulfonic acid. It is an anthropogenic (man-ma ...
(PFOS) mass spectrometry analysis.
References
Bile acids
Sulfonic acids
Carboxamides
Diols
Cholanes
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