Talopram (Lu 3-010),
also known as phthalapromine, is a
selective norepinephrine reuptake inhibitor
A norepinephrine reuptake inhibitor (NRI, NERI) or noradrenaline reuptake inhibitor or adrenergic reuptake inhibitor (ARI), is a type of drug that acts as a reuptake inhibitor for the neurotransmitters norepinephrine (noradrenaline) and epineph ...
(NRI) which was researched for the management of
depression in the 1960s and 1970s but was never commercialized. Along with
talsupram, talopram is
structurally
A structure is an arrangement and organization of interrelated elements in a material object or system, or the object or system so organized. Material structures include man-made objects such as buildings and machines and natural objects such as ...
related to the
selective serotonin reuptake inhibitor
Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions.
SSRIs increase the extracellul ...
(SSRI)
citalopram
Citalopram, sold under the brand name Celexa among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used to treat major depressive disorder, obsessive compulsive disorder, panic disorder, and socia ...
, as well as to
melitracen
Melitracen (brand names Melixeran) is a tricyclic antidepressant (TCA), for the treatment of depression and anxiety. In addition to single drug preparations, it is also available as Deanxit, marketed by Lundbeck, a combination product containi ...
:
Synthesis
An unexpected/fortuitous rearrangement product in the synthesis of
litracen is what led to talopram.
[
]
See also
* Talsupram (tasulopram)
* Amedalin
* Daledalin
*, 1969 (#15).
*Original literature
*Prindamine
Pirandamine (AY-23,713) is a tricyclic derivative which acts as a selective serotonin reuptake inhibitor (SSRI). It was investigated in the 1970s as a potential antidepressant but clinical development was not commenced and it was never marketed. ...
(21489-22-5)
References
Antidepressants
Norepinephrine reuptake inhibitors
Isobenzofurans
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