Tabernanthalog is a novel water-soluble, non-toxic azepinoindole
analog
Analog or analogue may refer to:
Computing and electronics
* Analog signal, in which information is encoded in a continuous variable
** Analog device, an apparatus that operates on analog signals
*** Analog electronics, circuits which use analog ...
of the psychoactive drug
ibogaine
Ibogaine is a naturally occurring psychoactive substance found in plants in the family Apocynaceae such as ''Tabernanthe iboga'', ''Voacanga africana'', and ''Tabernaemontana undulata''. It is a psychedelic with dissociative properties.
Prel ...
first synthesized by Professor
David E. Olson at
UC Davis.
[
*]
In
rodent
Rodents (from Latin , 'to gnaw') are mammals of the order Rodentia (), which are characterized by a single pair of continuously growing incisors in each of the upper and lower jaws. About 40% of all mammal species are rodents. They are na ...
s, it was found to promote structural neural plasticity, reduce drug seeking behavior, and produce
antidepressant
Antidepressants are a class of medication used to treat major depressive disorder, anxiety disorders, chronic pain conditions, and to help manage addictions. Common side-effects of antidepressants include dry mouth, weight gain, dizziness, hea ...
like effects.
Due to the rapidly-induced and enduring neuroplasticity, Tabernanthalog is a member of the class of compounds known as non-hallucinogenic
psychoplastogens.
[
*] This compound, as well as related compounds, are licensed by
Delix Therapeutics and are being developed as potential medicines for
neuropsychiatric disorders
A mental disorder, also referred to as a mental illness or psychiatric disorder, is a behavioral or mental pattern that causes significant distress or impairment of personal functioning. Such features may be persistent, relapsing and remitti ...
.
See also
*
PNU-22394
*
Psychoplastogen Psychoplastogens are a group of small molecule drugs that produce rapid and sustained effects on neuronal structure and function, intended to manifest therapeutic benefit after a single administration. Several existing psychoplastogens have been ...
*
Delix Therapeutics
*
David E. Olson
References
Tryptamines
Heterocyclic compounds with 3 rings
Methoxy compounds
{{heterocyclic-stub