Short transient receptor potential channel 5 (TrpC5) also known as transient receptor protein 5 (TRP-5) is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''TRPC5''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
TrpC5 is subtype of the
TRPC
TRPC is a family of transient receptor potential cation channels in animals.
TRPC channels form the subfamily of channels in humans most closely related to drosophila TRP channels. Structurally, members of this family possess a number of similar ...
family of
mammal
Mammals () are a group of vertebrate animals constituting the class Mammalia (), characterized by the presence of mammary glands which in females produce milk for feeding (nursing) their young, a neocortex (a region of the brain), fur or ...
ian
transient receptor potential
Transient receptor potential channels (TRP channels) are a group of ion channels located mostly on the plasma membrane of numerous animal cell types. Most of these are grouped into two broad groups: Group 1 includes TRPC ( "C" for canonical), TRP ...
ion channel
Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore. Their functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of io ...
s.
Function
TrpC5 is one of the seven mammalian
TRPC
TRPC is a family of transient receptor potential cation channels in animals.
TRPC channels form the subfamily of channels in humans most closely related to drosophila TRP channels. Structurally, members of this family possess a number of similar ...
(transient receptor potential canonical) proteins. TrpC5 is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with
TRPC1
Transient receptor potential canonical 1 (TRPC1) is a protein that in humans is encoded by the ''TRPC1'' gene.
Function
TRPC1 is an ion channel located on the plasma membrane of numerous human and animal cell types.
It is a nonspecific cation ...
,
TRPC3
Short transient receptor potential channel 3 (TrpC3) also known as transient receptor protein 3 (TRP-3) is a protein that in humans is encoded by the TRPC3 gene. The TRPC3/6/7 subfamily are implicated in the regulation of vascular tone, cell growt ...
, and
TRPC4. It also interacts with multiple proteins including
calmodulin
Calmodulin (CaM) (an abbreviation for calcium-modulated protein) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells. It is an intracellular target of the secondary messenger Ca2+, and the bind ...
,
CABP1,
enkurin
Enkurin is a protein that in humans is encoded by the ''ENKUR'' gene.
Enkurin interacts with transient receptor potential canonical (TRPC) cation channels (e.g., TRPC1
Transient receptor potential canonical 1 (TRPC1) is a protein that in humans ...
, Na
+–H
+ exchange regulatory factor (
NHERF
Sodium-hydrogen antiporter 3 regulator 1 is a regulator of Sodium-hydrogen antiporter 3. It is encoded by the gene ''SLC9A3R1''. It is also known as ERM Binding Protein 50 (EBP50) or Na+/H+ Exchanger Regulatory Factor (NHERF1). It is believed t ...
), interferon-induced GTP-binding protein (
MX1), ring finger protein 24 (
RNF24
Ring finger protein 24 is a protein that in humans is encoded by the ''RNF24'' gene.
RNF24 binds TRPC6 (603652) and other transient receptor potential cation channel (TRPC) family members and is involved in regulation of intracellular traffickin ...
), and
SEC14 domain and spectrin repeat-containing protein 1 (
SESTD1
SEC14 and spectrin domains 1, also known as SEC14 domain and spectrin repeat-containing protein 1 and Solo, is a protein that in humans is encoded by the ''SESTD1'' gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the w ...
).
TRPC4 and TRPC5 have been implicated in the mechanism of mercury toxicity and neurological behavior. It was established in 2021 that TRPC5 is a component of the dental cold sensing system.
Activation
Homomultimeric TRPC5 and heteromultimeric TRPC5-
TRPC1
Transient receptor potential canonical 1 (TRPC1) is a protein that in humans is encoded by the ''TRPC1'' gene.
Function
TRPC1 is an ion channel located on the plasma membrane of numerous human and animal cell types.
It is a nonspecific cation ...
channels are activated by extracellular reduced
thioredoxin
Thioredoxin is a class of small redox proteins known to be present in all organisms. It plays a role in many important biological processes, including redox signaling. In humans, thioredoxins are encoded by ''TXN'' and ''TXN2'' genes. Loss-of-func ...
.
This channel has also been found to be involved in the action of anaesthetics such as
chloroform
Chloroform, or trichloromethane, is an organic compound with chemical formula, formula Carbon, CHydrogen, HChlorine, Cl3 and a common organic solvent. It is a colorless, strong-smelling, dense liquid produced on a large scale as a precursor to ...
,
halothane
Halothane, sold under the brand name Fluothane among others, is a general anaesthetic. It can be used to induce or maintain anaesthesia. One of its benefits is that it does not increase the production of saliva, which can be particularly useful i ...
and
propofol
Propofol, marketed as Diprivan, among other names, is a short-acting medication that results in a decreased level of consciousness and a lack of memory for events. Its uses include the starting and maintenance of general anesthesia, sedation f ...
.
Interactions
TRPC5 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
STMN3
Stathmin-3 is a protein that in humans is encoded by the ''STMN3'' gene.
Function
The protein encoded by this gene belongs to the stathmin/oncoprotein 18 family of microtubule-destabilizing phosphoproteins. It is similar to the SCG10 protein an ...
,
TRPC1
Transient receptor potential canonical 1 (TRPC1) is a protein that in humans is encoded by the ''TRPC1'' gene.
Function
TRPC1 is an ion channel located on the plasma membrane of numerous human and animal cell types.
It is a nonspecific cation ...
,
and
TRPC4.
[
]
See also
* TRPC
TRPC is a family of transient receptor potential cation channels in animals.
TRPC channels form the subfamily of channels in humans most closely related to drosophila TRP channels. Structurally, members of this family possess a number of similar ...
References
Further reading
*
*
External links
*
Ion channels
{{membrane-protein-stub