TRNA (guanine
9-N
1)-methyltransferase (, ''Trm10p'', ''tRNA(m1G9/m1A9)-methyltransferase'', ''tRNA(m1G9/m1A9)MTase'', ''tRNA (guanine-N(1)-)-methyltransferase'', ''tRNA m1G9-methyltransferase'', ''tRNA m1G9 MTase'') is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
with
systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature.
A semisystematic name or semitrivial ...
''S-adenosyl-L-methionine:tRNA (guanine
9-N
1)-methyltransferase''.
This enzyme
catalyses the following
chemical reaction
A chemical reaction is a process that leads to the IUPAC nomenclature for organic transformations, chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the pos ...
:
S-adenosyl-L-methionine
''S''-Adenosyl methionine (SAM), also known under the commercial names of SAMe, SAM-e, or AdoMet, is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. Although these anabolic reactions occur through ...
+
guanine
Guanine () ( symbol G or Gua) is one of the four main nucleobases found in the nucleic acids DNA and RNA, the others being adenine, cytosine, and thymine (uracil in RNA). In DNA, guanine is paired with cytosine. The guanine nucleoside is called ...
9 in tRNA
S-adenosyl-L-homocysteine + N
1-methylguanine
9 in tRNA
The enzyme from ''
Saccharomyces cerevisiae
''Saccharomyces cerevisiae'' () (brewer's yeast or baker's yeast) is a species of yeast (single-celled fungus microorganisms). The species has been instrumental in winemaking, baking, and brewing since ancient times. It is believed to have been o ...
'' specifically methylates guanine
9.
References
External links
*
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EC 2.1.1