TRIM62, also called DEAR1 (for ductal epithelium–associated RING chromosome 1),
is a protein in the
tripartite motif family The tripartite motif family (TRIM) is a protein family.
Function
Many TRIM proteins are induced by interferons, which are important component of resistance to pathogens and several TRIM proteins are known to be required for the restriction of infe ...
. In human it is encoded by the gene ''TRIM62''.
''TRIM62'' is involved in the
morphogenesis
Morphogenesis (from the Greek ''morphê'' shape and ''genesis'' creation, literally "the generation of form") is the biological process that causes a cell, tissue or organism to develop its shape. It is one of three fundamental aspects of devel ...
of the
mammary gland
A mammary gland is an exocrine gland in humans and other mammals that produces milk to feed young offspring. Mammals get their name from the Latin word ''mamma'', "breast". The mammary glands are arranged in organs such as the breasts in primat ...
, and loss of ''TRIM62'' gene expression in breast is associated with a higher risk of recurrence in early-onset
breast cancer
Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, milk rejection, fluid coming from the nipple, a newly inverted nipple, or a re ...
.
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References
Developmental genes and proteins
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