CREB-regulated transcription coactivator 1 (CRTC1), previously referred to as TORC1 (''T''ransducer ''O''f ''R''egulated ''C''REB activity ''1''), is a
protein that in humans is encoded by the ''CRTC1''
gene.
It is expressed in a limited number of tissues that include fetal brain and liver and adult heart, skeletal muscles, liver and salivary glands
and various regions of the adult central nervous system.
Clinical significance
Production of CRTC1 is blocked in
Alzheimer's disease
Alzheimer's disease (AD) is a neurodegeneration, neurodegenerative disease that usually starts slowly and progressively worsens. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in short-term me ...
.
See also
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Transcription coregulator
References
Further reading
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External links
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Gene expression
Transcription coregulators
Immunology
Alzheimer's disease research
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