Transmembrane and ubiquitin-like domain-containing protein 2 is a protein that in humans is encoded by the ''TMUB2'' gene.

Gene

TMUB2 maps on the human chromosome 17, at locus 17q21.31. TMUB2 sits between two neighboring genes, ASB16-AS1 to the left and ATXN7L3 to the right. TMUB2 is 4.99 Kb long. The TMUB2 gene can be transcribed into three possible mRNA variants.

Expression

TMUB2 is likely ubiquitously expressed throughout the human body. It has a high expression level that is 2.9 times higher than other human genes.

Protein

The TMUB2 protein has a function that is not currently known. It consists of a 321 amino acid long chain in humans. The human protein has a molecular weight of 33.8 kdal, an isoelectric point of 4.73899, and three transmembrane regions. These will likely vary in orthologs.

Homology

Paralogs

TMUB1 is the only paralog of TMUB2. These proteins share a 38% identity and 51% similarity.

Orthologs

The table below presents a selection of some of the TMUB2 orthologs to display protein diversity among species.NCBI BLAST: Basic Local Alignment Search Tool
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Protein Interactions

In humans, Ubiquitin C (UBC) is a protein with a known interaction with TMUB2. Other proposed interactions include

BCL2L13 BCL2-like 13 (apoptosis facilitator), also known as BCL2L13 or Bcl-rambo, is a protein which in humans is encoded by the ''BCL2L13'' gene on chromosome 22. This gene encodes a mitochondrially-localized protein which is classified under the Bcl-2 p ...

(BCL2-like 13), SGTA (Small glutamine-rich tetratricopeptide repeat-containing protein), and

UBQLN1 Ubiquilin-1 is a protein that in humans is encoded by the ''UBQLN1'' gene. Ubiquilins contain two domains, an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubi ...

(Ubiquilin-1).BioGRID Database
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