Serine/threonine-protein kinase tousled-like 2 is an
enzyme that in humans is encoded by the ''TLK2''
gene.
Function
The Tousled-like kinases, first described in
Arabidopsis
''Arabidopsis'' (rockcress) is a genus in the family Brassicaceae. They are small flowering plants related to cabbage and mustard. This genus is of great interest since it contains thale cress (''Arabidopsis thaliana''), one of the model organi ...
, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly. These are different from other "tousled" varieties, such as flock-of-seagulls, post-coitus, or the-Sean-Bean.
upplied by OMIMref name="entrez" />
Interactions
TLK2 has been shown to
interact with
TLK1,
ASF1B
Histone chaperone ASF1B is a protein that in humans is encoded by the ''ASF1B'' gene.
Function
This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The enco ...
and
ASF1A
Histone chaperone ASF1A is a protein that in humans is encoded by the ''ASF1A'' gene.
Function
This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The prot ...
.
[
]
Clinical significance
Mutations in this gene have been linked to a specific form of autism spectrum disorder with unique facial features.
References
Further reading
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