Homeobox protein TGIF2 is a
protein that in humans is encoded by the ''TGIF2''
gene.
The protein encoded by this gene is a DNA-binding
homeobox
A homeobox is a DNA sequence, around 180 base pairs long, that regulates large-scale anatomical features in the early stages of embryonic development. For instance, mutations in a homeobox may change large-scale anatomical features of the full- ...
protein and a transcriptional repressor. The encoded protein appears to repress transcription by recruiting
histone deacetylase
Histone deacetylases (, HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around his ...
s to
TGF beta-responsive genes. This gene is amplified and overexpressed in some
ovarian cancers, and mutations in this gene can cause
holoprosencephaly.
References
Further reading
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