Transcription factor II E (TF_IIE) is one of several

general transcription factor General transcription factors (GTFs), also known as basal transcriptional factors, are a class of protein transcription factors that bind to specific sites (Promoter (genetics), promoter) on DNA to activate Transcription (genetics), transcription ...

s that make up the

RNA polymerase II RNA polymerase II (RNAP II and Pol II) is a multiprotein complex that transcribes DNA into precursors of messenger RNA (mRNA) and most small nuclear RNA (snRNA) and microRNA. It is one of the three RNAP enzymes found in the nucleus of eukaryoti ...

preinitiation complex. It is a tetramer of two alpha and two beta chains and interacts with TAF6/TAFII80, ATF7IP, and varicella-zoster virus IE63 protein. TF_IIE recruits TF_IIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TF_IIH. Both TF_IIH and TF_IIE are required for promoter clearance by RNA polymerase. Transcription factor II E is encoded by the

GTF2E1 General transcription factor IIE subunit 1 (GTF2E1), also known as transcription initiation factor IIE subunit alpha (TFIIE-alpha), is a protein that in humans is encoded by the ''GTF2E1'' gene In biology, the word gene (from , ; "... Wilhe ...

and

GTF2E2 General transcription factor IIE subunit 2 (GTF2E2), also known as transcription initiation factor IIE subunit beta (TFIIE-beta), is a protein that in humans is encoded by the ''GTF2E2'' gene In biology, the word gene (from , ; "...Wilhelm ...

genes. TF_IIE is thought to be involved in

DNA melting Nucleic acid thermodynamics is the study of how temperature affects the nucleic acid structure of double-stranded DNA (dsDNA). The melting temperature (''Tm'') is defined as the temperature at which half of the DNA strands are in the random coil o ...

at the promoter: it contains a zinc ribbon motif that can bind single stranded DNA.

References

External links

* Molecular genetics Proteins Gene expression Transcription factors {{gene-stub

See also

References

External links