Transcriptional enhancer factor TEF-5 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''TEAD3''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
This gene product is a member of the transcriptional enhancer factor (TEF) family of
transcription factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The fu ...
s, which contain the TEA/ATTS DNA-binding domain.
Members of the family in mammals are
TEAD1
Transcriptional enhancer factor TEF-1 also known as TEA domain family member 1 (TEAD1) and transcription factor 13 (TCF-13) is a protein that in humans is encoded by the ''TEAD1'' gene. TEAD1 was the first member of the TEAD family of transcriptio ...
,
TEAD2
TEAD2 (ETF, ETEF-1, TEF-4), together with TEAD1, defines a novel family of transcription factors, the TEAD family, highly conserved through evolution.
TEAD proteins were notably found in ''Drosophila'' (Scalloped), ''C. elegans'' (egl -44), ''S. ...
, TEAD3,
TEAD4
Transcriptional enhancer factor TEF-3 is a protein that in humans is encoded by the ''TEAD4'' gene.
Function
This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS ...
. Transcriptional coregulators, such as
WWTR1 (TAZ) bind to these transcription factors. TEAD3 is predominantly expressed in the
placenta
The placenta is a temporary embryonic and later fetal organ that begins developing from the blastocyst shortly after implantation. It plays critical roles in facilitating nutrient, gas and waste exchange between the physically separate mater ...
and is involved in the
transactivation In the context of gene regulation: transactivation is the increased rate of gene expression triggered either by biological processes or by artificial means, through the expression of an intermediate transactivator protein.
In the context of recep ...
of the
chorionic somatomammotropin-B gene enhancer. It is expressed in nervous system and muscle in fish embryos.
Translation of this protein is initiated at a non-AUG (AUA)
start codon
The start codon is the first codon of a messenger RNA (mRNA) transcript translated by a ribosome. The start codon always codes for methionine in eukaryotes and Archaea and a N-formylmethionine (fMet) in bacteria, mitochondria and plastids. The ...
.
References
Further reading
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External links
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Transcription factors
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