Transcriptional adapter 2-alpha is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''TADA2A''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Two transcript variants encoding different isoforms have been identified for this gene.
Interactions
TADA2L has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
GCN5L2
__NOTOC__
Histone acetyltransferase KAT2A is an enzyme that in humans is encoded by the ''KAT2A'' gene.
Interactions
GCN5L2 has been shown to interact with:
* DDB1,
* Ku70,
* Ku80
Ku80 is a protein that, in humans, is encoded by the ''XRCC5 ...
,
TADA3L
Transcriptional adapter 3-like is a protein that in humans is encoded by the ''TADA3'' gene. Cytogenetic location: 3p25.3
Function
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated ge ...
and
Myc
''Myc'' is a family of regulator genes and proto-oncogenes that code for transcription factors. The ''Myc'' family consists of three related human genes: ''c-myc'' (MYC), ''l-myc'' ( MYCL), and ''n-myc'' (MYCN). ''c-myc'' (also sometimes refe ...
.
References
Further reading
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{{PDB Gallery, geneid=6871