The ''Streptomycetaceae'' are a

family Family (from la, familia) is a group of people related either by consanguinity (by recognized birth) or affinity (by marriage or other relationship). The purpose of the family is to maintain the well-being of its members and of society. Idea ...

of ''

Actinomycetota The ''Actinomycetota'' (or ''Actinobacteria'') are a phylum of all gram-positive bacteria. They can be terrestrial or aquatic. They are of great economic importance to humans because agriculture and forests depend on their contributions to s ...

'', making up the

monotypic In biology, a monotypic taxon is a taxonomic group (taxon) that contains only one immediately subordinate taxon. A monotypic species is one that does not include subspecies or smaller, infraspecific taxa. In the case of genera, the term "unispe ...

order Order, ORDER or Orders may refer to: * Categorization, the process in which ideas and objects are recognized, differentiated, and understood * Heterarchy, a system of organization wherein the elements have the potential to be ranked a number of ...

''Streptomycetales''. It includes the important genus ''

Streptomyces ''Streptomyces'' is the largest genus of Actinomycetota and the type genus of the family Streptomycetaceae. Over 500 species of ''Streptomyces'' bacteria have been described. As with the other Actinomycetota, streptomycetes are gram-positiv ...

''. This was the original source of many

antibiotics An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and preventio ...

, namely

streptomycin Streptomycin is an antibiotic medication used to treat a number of bacterial infections, including tuberculosis, ''Mycobacterium avium'' complex, endocarditis, brucellosis, ''Burkholderia'' infection, plague, tularemia, and rat bite fever. F ...

, the first antibiotic against

tuberculosis Tuberculosis (TB) is an infectious disease usually caused by '' Mycobacterium tuberculosis'' (MTB) bacteria. Tuberculosis generally affects the lungs, but it can also affect other parts of the body. Most infections show no symptoms, ...

Genomics

Sequence alignments of

actinomycetota The ''Actinomycetota'' (or ''Actinobacteria'') are a phylum of all gram-positive bacteria. They can be terrestrial or aquatic. They are of great economic importance to humans because agriculture and forests depend on their contributions to s ...

l genomes have led to the identification of three

conserved signature indels Conserved signature inserts and deletions (CSIs) in protein sequences provide an important category of molecular markers for understanding phylogenetic relationships. CSIs, brought about by rare genetic changes, provide useful phylogenetic markers ...

which are unique to the order Streptomycetales. The enzyme PBGD contains a four-amino-acid insertion which is present in all ''Streptomyces'' species and ''Kitasatospora setae'', but not any other Actinomycetota. Similarly, a one- amino-acid insertion is present in a conserved region of

adenylate kinase Adenylate kinase ( ECbr>2.7.4.3 (also known as ADK or myokinase) is a phosphotransferase enzyme that catalyzes the interconversion of the various adenosine phosphates (ATP, ADP, and AMP). By constantly monitoring phosphate nucleotide levels inside ...

and is found in all ''Streptomyces'' species and '' K. setae'', but is not found in any other Actinomycetota. Five conserved signature proteins have also been identified which are present in various sequenced ''Streptomyces'' species, but not in ''K. setae''; however, as the complete genome of ''K. setae'' has not yet been sequenced, these proteins may be present in ''K. setae''. Additionally, 11 conserved signature proteins have been identified which are found in all sequenced ''Streptomyces'' species and ''K. setae''. These proteins are believed to be unique to the Streptomycetales order, thus provide

molecular markers A molecular marker is a molecule, sampled from some source, that gives information about its source. For example, DNA is a molecular marker that gives information about the organism from which it was taken. For another example, some proteins can be ...

which can be used to distinguish this group from the rest of the Actinomycetota. Phylogenetic trees indicate that the order

Catenulisporales The ''Catenulisporales'' are an order of bacteria. References Actinomycetia Bacteria orders {{actinobacteria-stub ...

is closely related to the order Streptomycetales. This inference is supported by a one-amino-acid conserved signature indel which is uniquely found in all Streptomycetales species and ''Catenulisporales acidiphilia'', the only Catenulisporales species whose complete genome has been sequenced. Additionally, three conserved signature proteins have been identified which are found in all Streptomycetales species and ''C. acidiphilia''. Both the conserved signature indel and the conserved signature proteins provide evidence that the orders Streptomycetales and Catenulisporales are closely related.

Phylogeny

The accepted taxonomy is based on the

List of Prokaryotic names with Standing in Nomenclature List of Prokaryotic names with Standing in Nomenclature (LPSN) is an online database that maintains information on the nomenclature, naming and Taxonomy (biology), taxonomy of prokaryotes, following the taxonomy requirements and rulings of the In ...

Genomics

Phylogeny

Notes

References

External links