Simian Immunodeficiency Virus
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''Simian immunodeficiency virus'' (''SIV'') is a species of
retrovirus A retrovirus is a type of virus that inserts a DNA copy of its RNA genome into the DNA of a host cell that it invades, thus changing the genome of that cell. Once inside the host cell's cytoplasm, the virus uses its own reverse transcriptase ...
that cause persistent infections in at least 45 species of non-human
primate Primates are a diverse order of mammals. They are divided into the strepsirrhines, which include the lemurs, galagos, and lorisids, and the haplorhines, which include the tarsiers and the simians (monkeys and apes, the latter including huma ...
s. Based on analysis of strains found in four species of
monkeys Monkey is a common name that may refer to most mammals of the infraorder Simiiformes, also known as the simians. Traditionally, all animals in the group now known as simians are counted as monkeys except the apes, which constitutes an incomple ...
from
Bioko Island Bioko (; historically Fernando Po; bvb, Ëtulá Ëria) is an island off the west coast of Africa and the northernmost part of Equatorial Guinea. Its population was 335,048 at the 2015 census and it covers an area of . The island is located of ...
, which was isolated from the mainland by
rising sea levels Rising may refer to: * Rising, a stage in baking - see Proofing (baking technique) *Elevation * Short for Uprising, a rebellion Film and TV * "Rising" (''Stargate Atlantis''), the series premiere of the science fiction television program ''Starga ...
about 11,000 years ago, it has been concluded that SIV has been present in monkeys and apes for at least 32,000 years, and probably much longer. Virus
strain Strain may refer to: Science and technology * Strain (biology), variants of plants, viruses or bacteria; or an inbred animal used for experimental purposes * Strain (chemistry), a chemical stress of a molecule * Strain (injury), an injury to a mu ...
s from three of these primate species, SIVsmm in
sooty mangabey The sooty mangabey (''Cercocebus atys'') is an Old World monkey found in forests from Senegal in a margin along the coast down to the Ivory Coast. Habitat and ecology The sooty mangabey is native to tropical West Africa, being found in Guinea, G ...
s, SIVgor in
gorilla Gorillas are herbivorous, predominantly ground-dwelling great apes that inhabit the tropical forests of equatorial Africa. The genus ''Gorilla'' is divided into two species: the eastern gorilla and the western gorilla, and either four or fi ...
s and SIVcpz in
chimpanzees The chimpanzee (''Pan troglodytes''), also known as simply the chimp, is a species of great ape native to the forest and savannah of tropical Africa. It has four confirmed subspecies and a fifth proposed subspecies. When its close relative the ...
, are believed to have crossed the species barrier into humans, resulting in
HIV-2 The subtypes of HIV include two major types, HIV type 1 (HIV-1) and HIV type 2 (HIV-2). HIV-1 is related to viruses found in chimpanzees and gorillas living in western Africa, while HIV-2 viruses are related to viruses found in the sooty mangabey, ...
and
HIV-1 The subtypes of HIV include two major types, HIV type 1 (HIV-1) and HIV type 2 (HIV-2). HIV-1 is related to viruses found in chimpanzees and gorillas living in western Africa, while HIV-2 viruses are related to viruses found in the sooty mangabey ...
respectively, the two
HIV The human immunodeficiency viruses (HIV) are two species of ''Lentivirus'' (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immune ...
viruses. The most likely route of transmission of HIV-1 to humans involves contact with the blood of chimps and gorillas that are often hunted for bushmeat in Africa. Four subtypes of HIV-1 (M, N, O, and P) likely arose through four separate transmissions of SIV to humans, and the resulting HIV-1 group M strain most commonly infects people worldwide. Therefore, it is theorized that SIV may have previously crossed the species barrier into human hosts multiple times throughout history, but it was not until recently, after the advent of modern transportation and global commuterism, that it finally took hold, spreading beyond localized decimations of a few individuals or single small tribal populations. Unlike HIV-1 and HIV-2 infections in humans, SIV infections in their natural simian non-human hosts appear in many cases to be non-pathogenic due to evolutionary adaptation of the hosts to the virus. Extensive studies in sooty mangabeys have established that SIVsmm infection does not cause any disease in these primates, despite high levels of circulating virus. Regulation of the activity
CCR5 C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved in the immune system as it acts as a receptor for chemokines. In humans, the ''CCR5'' gene that encodes the CCR5 p ...
coreceptor is one of the natural strategies to avoid disease in some natural host species of SIV. Unlike SIVsmm infection in sooty mangabeys, a recent study of SIVcpz in wild living chimpanzees suggests that infected chimpanzees experience an AIDS-like illness similar to HIV-1 infected humans. The later stages of SIV infection develop into sAIDS, much like how HIV infection develops into AIDS.


Taxonomy

The
ICTVdB The International Committee on Taxonomy of Viruses (ICTV) authorizes and organizes the taxonomic classification of and the nomenclatures for viruses. The ICTV has developed a universal taxonomic scheme for viruses, and thus has the means to ap ...
code of SIV is 61.0.6.5.003. The simian (monkey-hosted) immunodeficiency viruses are a species of retrovirus in the Primate group of genus ''
Lentivirus ''Lentivirus'' is a genus of retroviruses that cause chronic and deadly diseases characterized by long incubation periods, in humans and other mammalian species. The genus includes the human immunodeficiency virus (HIV), which causes AIDS. Lent ...
'' along with the human viruses
HIV-1 The subtypes of HIV include two major types, HIV type 1 (HIV-1) and HIV type 2 (HIV-2). HIV-1 is related to viruses found in chimpanzees and gorillas living in western Africa, while HIV-2 viruses are related to viruses found in the sooty mangabey ...
and
HIV-2 The subtypes of HIV include two major types, HIV type 1 (HIV-1) and HIV type 2 (HIV-2). HIV-1 is related to viruses found in chimpanzees and gorillas living in western Africa, while HIV-2 viruses are related to viruses found in the sooty mangabey, ...
that cause AIDS, and a few other viruses that infect other primates. Related viruses in other groups in the genus infect other mammals like sheep and goats, horses, cattle, cats and a few others. The genus is one of 6 genera in subfamily
orthoretrovirinae ''Orthoretrovirinae'' is a subfamily of viruses belonging to ''Retroviridae'', a family of enveloped viruses that replicate in a host cell through the process of reverse transcription. The subfamily currently includes six genera, of which ''Lent ...
which together with genus ''
Spumavirus ''Spumaretrovirinae'', commonly called spumaviruses (, Latin for "foam") or foamyviruses, is a subfamily of the ''Retroviridae'' family. ICTVMaster Species List 2018a v1MSL including all taxa updates since the 2017 release. Fall 2018 (MSL #33) Sp ...
'' form family
retroviridae A retrovirus is a type of virus that inserts a DNA copy of its RNA genome into the DNA of a host cell that it invades, thus changing the genome of that cell. Once inside the host cell's cytoplasm, the virus uses its own reverse transcriptase e ...
of all RNA retroviruses (RNA viruses which use a DNA intermediate). The order to which family retroviridae belongs is not specified. The taxonomic relationship between RNA retroviruses and other RNA viruses and DNA viruses has not been specified. SIV retroviruses are in group vi (positive-sense single-stranded retroviruses) of the
Baltimore classification Baltimore classification is a system used to classify viruses based on their manner of messenger RNA (mRNA) synthesis. By organizing viruses based on their manner of mRNA production, it is possible to study viruses that behave similarly as a di ...
system.


Strains

While human immunodeficiency virus has a limited number of subtypes, SIV is now known to infect a few dozen species of non-human primates, and distinct strains are often associated with each species, or with a set of closely related species. The thus far categorized ~40 strains are divided into 5 distinct groups and one subgroup: * i) HIV-1, SIVcpz (
chimpanzee The chimpanzee (''Pan troglodytes''), also known as simply the chimp, is a species of great ape native to the forest and savannah of tropical Africa. It has four confirmed subspecies and a fifth proposed subspecies. When its close relative th ...
), SIVgor (
gorilla Gorillas are herbivorous, predominantly ground-dwelling great apes that inhabit the tropical forests of equatorial Africa. The genus ''Gorilla'' is divided into two species: the eastern gorilla and the western gorilla, and either four or fi ...
), SIVrcm (
red-capped mangabey The collared mangabey (''Cercocebus torquatus''), also called red-capped mangabey and white-collared mangabey is a species of primate in the family Cercopithecidae of Old World monkeys. It formerly included the sooty mangabey as a subspecies. ...
), SIVagi (
agile mangabey The agile mangabey (''Cercocebus agilis'') is an Old World monkey of the white-eyelid mangabey group found in swampy forests of Central Africa in Equatorial Guinea, Cameroon, Gabon, Central African Republic, Republic of Congo, and DR Congo. Unti ...
), SIVmnd 2 (
mandrill The mandrill (''Mandrillus sphinx'') is a large Old World monkey native to west central Africa. It is one of the most colorful mammals in the world, with red and blue skin on its face and posterior. The species is sexually dimorphic, as males ...
), SIVdrl (
drill monkey A drill is a tool used for making round holes or driving fasteners. It is fitted with a bit, either a drill or driverchuck. Hand-operated types are dramatically decreasing in popularity and cordless battery-powered ones proliferating due to i ...
) * ii) HIV-2, SIVsmm (
sooty mangabey The sooty mangabey (''Cercocebus atys'') is an Old World monkey found in forests from Senegal in a margin along the coast down to the Ivory Coast. Habitat and ecology The sooty mangabey is native to tropical West Africa, being found in Guinea, G ...
), SIVmac (
rhesus macaque The rhesus macaque (''Macaca mulatta''), colloquially rhesus monkey, is a species of Old World monkey. There are between six and nine recognised subspecies that are split between two groups, the Chinese-derived and the Indian-derived. Generally b ...
), SIVmne (
pig-tailed macaque The pig-tailed macaques are two macaque sister species. They look almost identical and are best distinguished by their parapatric ranges: * Northern pig-tailed macaque, ''Macaca leonina'' (Bangladesh to Vietnam, south to northern Malaysia) * South ...
), SIVstm ( stump-tailed macaque) * iii) SIVagm eneric(
African green monkeys ''Chlorocebus'' is a genus of medium-sized primates from the family of Old World monkeys. Six species are currently recognized, although some people classify them all as a single species with numerous subspecies. Either way, they make up the enti ...
): SIVsab, SIVver, SIVgri ( grivet monkey), SIVtan (
tantalus monkey The tantalus monkey (''Chlorocebus tantalus'') is an Old World monkey from Africa that ranges from Ghana to Sudan. It was originally described as a subspecies of the grivet (''Chlorocebus aethiops''). All species in ''Chlorocebus'' were formerly ...
) * iv) SIVmnd 1 (
mandrill The mandrill (''Mandrillus sphinx'') is a large Old World monkey native to west central Africa. It is one of the most colorful mammals in the world, with red and blue skin on its face and posterior. The species is sexually dimorphic, as males ...
), SIVlho (
L'hoest's monkey L'Hoest's monkey (''Allochrocebus lhoesti'') or mountain monkey, is a guenon found in the upper eastern Congo basin. They mostly live in mountainous forest areas in small, female-dominated groups. They have a dark coat and can be distinguishe ...
), SIVsun (
sun-tailed monkey The sun-tailed monkey (''Allochrocebus solatus'') from Gabon is one of the least studied primates in its habitat. It was discovered as a new species in 1988, and is classified as a guenon, which is a member of the genus ''Cercopithecus'', but was ...
), SIVprg (
Preuss's guenon The Preuss's monkey (''Allochrocebus preussi''), also known as Preuss's guenon, is a diurnal primate that lives terrestrially in mountainous (up to 2500 m) forests of eastern Nigeria, western Cameroon and Bioko in Equatorial Guinea. It was form ...
), SIVwrc (
western red colobus The western red colobus (''Piliocolobus badius''), also known as the bay red colobus, rust red colobus or Upper Guinea red colobus, is a species of Old World monkey in West African forests from Senegal to Ghana. All other species of red colobuses ...
), SIVolc (
olive colobus The olive colobus monkey (''Procolobus verus''), also known as the green colobus or Van Beneden's colobus, is a species of primate in the family Cercopithecidae. Its English name refers to its dull olive upperparts. It is the smallest example ...
), SIVkrc (
Kibale red colobus Kibaale is a town in the Western Region of Uganda. It is the main municipal, administrative, and commercial center of Kibaale District, and the district headquarters are located there. Location Kibaale is in Buyaga County, approximately , by roa ...
), SIVtrc ( Tshuapa red colobus) * v) SIVsyk (
Sykes' monkey Sykes' monkey (''Cercopithecus albogularis''), also known as the white-throated monkey or Samango monkey, is an Old World monkey found between Ethiopia and South Africa, including south and east Democratic Republic of Congo. It is named after Eng ...
), SIVdeb (
De Brazza's monkey De Brazza's monkey (''Cercopithecus neglectus'') is an Old World monkey endemic to the riverine and swamp forests of central Africa. The largest species in the guenon family, it is one of the most widespread arboreal African primates. Aside from ...
), SIVden (
Dent's mona monkey Dent's mona monkey (''Cercopithecus denti'') is an Old World monkey in the family Cercopithecidae found in the Democratic Republic of the Congo, the Congo, Rwanda, western Uganda, and the Central African Republic. It was previously classified ...
), SIVwol (
Wolf's mona monkey Wolf's mona monkey (''Cercopithecus wolfi''), also called Wolf's guenon, is a colourful Old World monkey in the family Cercopithecidae. It is found in central Africa, primarily between the Democratic Republic of the Congo and Uganda. It lives in ...
), SIVgsn/SIVmon/SIVmus 1/SIVmus 2 clade, SIVtal ( northern talapoin), SIVasc (
red-tailed guenon The red-tailed monkey (''Cercopithecus ascanius''), also known as the black-cheeked white-nosed monkey, red-tailed guenon, redtail monkey, or Schmidt's guenon, is a species of primate in the family Cercopithecidae. It is found in Angola, Cameroo ...
), SIVbkm (
black mangabey The black crested mangabey (''Lophocebus aterrimus'') is a species of primate in the family Cercopithecidae. It is only found in Democratic Republic of the Congo with a small habitat extending to Angola. Its natural habitat is subtropical or tro ...
), SIVreg ormerly SIVery(
red-eared guenon The red-eared guenon (''Cercopithecus erythrotis''), also called red-eared monkey, or russet-eared guenon is a primate species in the family Cercopithecidae. It is native to subtropical and tropical moist lowland forests in Cameroon, Equatorial ...
), SIVblu (blue monkey) ** vi) SIVcol ( colobus guereza), SIVkcol 1 ( black-and-white colobus), SIVkcol 2, SIVblc (formerly SIVbcm) (
black colobus The black colobus (''Colobus satanas''), or satanic black colobus, is a species of Old World monkey belonging to the genus ''Colobus''. The species is found in a small area of western central Africa. Black colobuses are large, completely covered ...
),


History

Immunodeficiency resembling human AIDS was reported in captive monkeys in the United States beginning in 1983. SIV was isolated in 1985 from some of these animals, captive
rhesus macaque The rhesus macaque (''Macaca mulatta''), colloquially rhesus monkey, is a species of Old World monkey. There are between six and nine recognised subspecies that are split between two groups, the Chinese-derived and the Indian-derived. Generally b ...
s suffering from simian AIDS (SAIDS). The discovery of SIV was made shortly after HIV-1 had been isolated as the cause of AIDS and led to the discovery of HIV-2 strains in West Africa. HIV-2 was more similar to the then-known SIV strains than to HIV-1, suggesting for the first time the simian origin of HIV. Further studies indicated that HIV-2 is derived from the SIVsmm strain found in sooty mangabeys, whereas HIV-1, the predominant virus found in humans, is derived from SIV strains infecting chimpanzees (SIVcpz). Chimpanzees are not believed to be the original hosts of an independent lineage of SIV, but rather that SIVcpz is a relatively recent acquisition resulting from a recombination of SIVgsn (
greater spot-nosed monkey The greater spot-nosed monkey or putty-nosed monkey (''Cercopithecus nictitans'') is one of the smallest Old World monkeys. It is a guenon of the '' C. mitis'' group, native to West Africa and living to some extent in rain forests, but more often ...
s) and SIVrcm (
red-capped mangabey The collared mangabey (''Cercocebus torquatus''), also called red-capped mangabey and white-collared mangabey is a species of primate in the family Cercopithecidae of Old World monkeys. It formerly included the sooty mangabey as a subspecies. ...
s) within the host chimpanzee. It is known that chimpanzees hunt and consume these monkeys for food. In 2010, researchers reported that SIV had infected monkeys in
Bioko Bioko (; historically Fernando Po; bvb, Ëtulá Ëria) is an island off the west coast of Africa and the northernmost part of Equatorial Guinea. Its population was 335,048 at the 2015 census and it covers an area of . The island is located of ...
for at least 32,000 years. Based on
molecular clock The molecular clock is a figurative term for a technique that uses the mutation rate of biomolecules to deduce the time in prehistory when two or more life forms diverged. The biomolecular data used for such calculations are usually nucleoti ...
analyses of sequences, it was previously thought by many that SIV infection in monkeys had happened over the past few hundred years. Scientists estimated that it would take a similar amount of time before humans would adapt naturally to HIV infection in the way monkeys in Africa have adapted to SIV and not suffer any harm from the infection. In 2008, discovery of an endogenous lentivirus in a prosimian (proto-monkey) primate, the gray mouse lemur native to Madagascar, pushed the origin of SIV-like lentivirus infections in primates back to at least 14 Ma, the last time there was intermingling of mammals between the island of Madagascar and the African mainland, if the infection is attributed to horizontal transmission between homologous hosts. If the virus and host were coevolved, rather than acquired, that potentially pushes the date of the endogenous event back to approx. 85 Ma, the split between the lemur-like and monkey-like primate lineages. That date barely antedates the emergence of the primates 87.7 Ma.


Virology


Structure and genome

The SIV virion is a spherical to pleomorphic glycoprotein envelope 110-120 nm enclosing a 110x50nm truncated cone or wedge-shaped (occasionally rod) capsid containing a
dimer Dimer may refer to: * Dimer (chemistry), a chemical structure formed from two similar sub-units ** Protein dimer, a protein quaternary structure ** d-dimer * Dimer model, an item in statistical mechanics, based on ''domino tiling'' * Julius Dimer ...
ic pair of positive-sense single-stranded RNA genome.


Genome

* coding regions


Proteome

* genes: ''env'', ''gag'', ''pol'', ''tat'', ''rev'', ''nef'', ''vpr'', ''vif'', ''vpu/vpx'' * Structural proteins (envelope): SU, TM,(gag): MA, CA, NC * Enzymes: RT, PR, IN * Gene regulators: Tat, Rev * Accessory proteins: Nef, Vpr, Vpx, Vif


Tropism

Differences in species specificity of SIV and related retroviruses may be partly explained by variants of the protein TRIM5α in humans and non-human primate species. This intracellular protein recognizes the
capsid A capsid is the protein shell of a virus, enclosing its genetic material. It consists of several oligomeric (repeating) structural subunits made of protein called protomers. The observable 3-dimensional morphological subunits, which may or may ...
of various retroviruses and blocks their reproduction. Other proteins such as
APOBEC3G APOBEC3G (apolipoprotein B mRNA editing enzyme, catalytic subunit 3G) is a human enzyme encoded by the ''APOBEC3G'' gene that belongs to the APOBEC superfamily of proteins. This family of proteins has been suggested to play an important role in ...
/ 3F that exerts antiretroviral immune activity, may also be important in restricting cross-species transmission.


Replication

* Attachment * Penetration * Uncoating * Replication ** reverse transcription +ssRNA → -ssDNA → dsDNA → +ssRNA (viral genome) → +ssmRNA → viral protein :*integration :*latency :*cleavage :*protein synthesis :*Assembly * Budding * Maturation


Quasispecies

The speed and transcription inaccuracies of RNA viruses give rise to antigenically distinct varieties in a single host animal. These ''
quasispecies The quasispecies model is a description of the process of the Darwinian evolution of certain self-replicating entities within the framework of physical chemistry. A quasispecies is a large group or "cloud" of related genotypes that exist in an en ...
'' don't necessarily give rise to population-wide new organisms. The rate of proliferation of quasispecies has significant implication for host immune control, and therefore virulence of the organism.


Pathogenesis

SIV pathogenesis encompasses both pathogenic and non-pathogenic SIV infections. SIV infection of non-human primates (NHPs) invariably results in persistent infection, but rarely acute disease. Pathogenic infection is typified by Rhesus macaques infected with SIV strains derived from sooty mangabeys. Disease progression to AIDS occurs within a period of months to years, depending upon the SIV strain used. Non-pathogenic infection is typified by African NHPs naturally infected with SIV. These animals rarely progress to AIDS despite maintaining viral loads that are equivalent to SIV viral loads in pathogenic infections. It is postulated that AIDS-like disease in African NHPs represents horizontal transmission of the virus from one or more homologous species in the recent evolutionary past, before equilibrium of co-adaptation has occurred.


SIV/HIV infection similarities and differences

The similarities of the two types of virus infections: * high level of virus replication during primary infection (0–180 days) * high level of CD4+ T-cell loss (0–180 days) * restricted role of humoral immune response The differences (what happens in primates): * lower level of CCR5+ T-cells * stable level of viral replication (180 days-years) * restoration of CD4+ T-cells * early cytokine production (0–10 days after infection) * normal level of immune activation * high level of functional immune cells * establishment of anti-inflamatory milieu


Epidemiology

Beatrice Hahn of the
University of Pennsylvania The University of Pennsylvania (also known as Penn or UPenn) is a private research university in Philadelphia. It is the fourth-oldest institution of higher education in the United States and is ranked among the highest-regarded universitie ...
and a team of researchers in 2009 found that chimpanzees do die from simian AIDS in the wild and that the AIDS outbreak in Africa has contributed to the decline of chimpanzee populations. Testing wild chimpanzees, researchers detected organ and tissue damage similar to late-stage human AIDS. The infected chimpanzees had a 10 to 16 times greater risk of dying than uninfected ones; infected females were less likely to give birth, could pass the virus to their infants, and had a higher infant mortality rate than uninfected females.
Bonobo The bonobo (; ''Pan paniscus''), also historically called the pygmy chimpanzee and less often the dwarf chimpanzee or gracile chimpanzee, is an endangered great ape and one of the two species making up the genus '' Pan,'' the other being the comm ...
s appear to avoid simian immunodeficiency virus (SIV) and its effects, though it is not known why. African green monkeys (also called vervets, genus Chlorocebus) in African populations are heavily infected with SIVagm, while the virus is absent in the founder isolate vervet populations in the Caribbean. The prevalence of SIV infection in African populations ranges 78-90% in adult females and 36-57% in adult males, while SIV infection is rare in immature individuals. SIV infected vervets in the wild do not develop chronic immune activation or microbial translocation (assessed by sCD14 as a surrogate biomarker). During natural SIV infection, the gut microbiome showed a significant increase in microbial diversity, a decrease in Proteobacteria/Succinivibrio and an increase of Veillonella, and a decrease in genes involved in pathways of microbial invasion, and partial reversibility of acute infection-related shifts in microbial abundance. The pattern of natural selection in the monkey genome in genes involved in HIV responses and those regulated in response to experimental SIV infection in monkeys, but not macaques, suggests a natural adaptation to SIV in Chlorocebus monkeys in Africa.


Vaccine research

In 2012, researchers reported that initial infection of
rhesus monkeys The rhesus macaque (''Macaca mulatta''), colloquially rhesus monkey, is a species of Old World monkey. There are between six and nine recognised subspecies that are split between two groups, the Chinese-derived and the Indian-derived. Generally b ...
by neutralization-resistant SIV strains could be partially prevented through use of an anti-SIVSME543 vaccine obligately including Env protein antigens. In 2013, a study by a group of authors reported on successful testing of a vaccine containing SIV protein-expressing rhesus cytomegalovirus vector. Approximately 50% of vaccinated rhesus macaques manifested durable, aviraemic control of infection with the highly pathogenic strain SIVmac239.


See also

*
HIV The human immunodeficiency viruses (HIV) are two species of ''Lentivirus'' (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immune ...
, the human version of SIV which causes AIDS *
Positive-sense single-stranded RNA virus Positive-strand RNA viruses (+ssRNA viruses) are a group of related viruses that have positive-sense, single-stranded genomes made of ribonucleic acid. The positive-sense genome can act as messenger RNA (mRNA) and can be directly translated i ...
, a classification which includes SIV *
Zoonosis A zoonosis (; plural zoonoses) or zoonotic disease is an infectious disease of humans caused by a pathogen (an infectious agent, such as a bacterium, virus, parasite or prion) that has jumped from a non-human (usually a vertebrate) to a human. ...
and Origin of AIDS, transmission from other primates to humans *
List of zoonotic primate viruses The following list of primate viruses is not exhaustive. Many viruses specific to non-human primates nevertheless are known to ''jump'' and infect humans and, thus, become known as zoonoses. {, class="wikitable" , - ! style="background:#ccf;", ...
* Other simian exogenous retroviruses:
simian-T-lymphotropic virus Simian-T-lymphotropic viruses, also Simian T-cell leukemia viruses (STLVs), are retroviruses closely related to the human sexually and breastfeeding transmissible viruses HTLV. They have subtypes 1 through 4 as compared to HTLV 1 through 4, and ...
, simian retrovirus type D, gibbon-ape leukemia virus,
simian foamy virus ''Simian foamy virus'' (''SFV'') is a species of the genus ''Spumavirus'' that belongs to the family of ''Retroviridae''. It has been identified in a wide variety of primates, including prosimians, New World and Old World monkeys, as well as ap ...
,
simian sarcoma virus Woolly monkey sarcoma virus (WMSV), with synonym Simian sarcoma virus (often abbreviated by SSV, but this may also stand for some species called ' Sulfolobus spindle-shaped virus', that belong to different genera in family Fuselloviridae) is a ...
* Related viruses also cause disease in other mammals:
sheep Sheep or domestic sheep (''Ovis aries'') are domesticated, ruminant mammals typically kept as livestock. Although the term ''sheep'' can apply to other species in the genus ''Ovis'', in everyday usage it almost always refers to domesticated s ...
,
goats The goat or domestic goat (''Capra hircus'') is a domesticated species of Caprinae, goat-antelope typically kept as livestock. It was domesticated from the wild goat (''C. aegagrus'') of Southwest Asia and Eastern Europe. The goat is a membe ...
,
cats The cat (''Felis catus'') is a domestic species of small carnivorous mammal. It is the only domesticated species in the family Felidae and is commonly referred to as the domestic cat or house cat to distinguish it from the wild members of t ...
,
cattle Cattle (''Bos taurus'') are large, domesticated, cloven-hooved, herbivores. They are a prominent modern member of the subfamily Bovinae and the most widespread species of the genus ''Bos''. Adult females are referred to as cows and adult mal ...
,
horses The horse (''Equus ferus caballus'') is a domesticated, one-toed, hoofed mammal. It belongs to the taxonomic family Equidae and is one of two extant subspecies of ''Equus ferus''. The horse has evolved over the past 45 to 55 million yea ...
*
SV40 SV40 is an abbreviation for simian vacuolating virus 40 or simian virus 40, a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that has the potential to cause tumors in animals, but most often ...
is another virus that came from simians and into human populations in the mid twentieth century.


References


Further reading


"HIV origin 'found in wild chimps'"
BBC News article * Peeters ''et al.''
"Risk to Human Health from a Plethora of Simian Immunodeficiency Viruses in Primate Bushmeat"
''Emerging Infectious Diseases'', Vol 8, No 5, May 2002. Contains a picture of the relationship among the various SIV/HIV strains.


External links



including links to subspecies and sequence data, from the
International Committee on Taxonomy of Viruses The International Committee on Taxonomy of Viruses (ICTV) authorizes and organizes the taxonomic classification of and the nomenclatures for viruses. The ICTV has developed a universal taxonomic scheme for viruses, and thus has the means to app ...
{{DEFAULTSORT:Simian Immunodeficiency Virus Lentiviruses Primate diseases Animal viral diseases