''Shigella dysenteriae'' is a species of the rod-shaped bacteria
''. ''Shigella'' species can cause shigellosis
). Shigellae are Gram-negative
, facultatively anaerobic
''S. dysenteriae'' has the ability to invade and replicate in various species of epithelial cells
Shigella infections may be contracted by a lack of monitoring of water and food quality, unsanitary cooking conditions and improper hygiene practices.
''S. dysenteriae'' spreads through contaminated water and food, causes minor dysentery
because of its Shiga toxin
, but other species may also be dysentery agents. ''S. dysenteriae'' releases an exotoxin that compromises the gut and central nervous system.
If acting as an enterotoxin
will occur. When acting as a neurotoxin
, severe cases of shigellosis
are developed, inducing comas
Contamination is often caused by bacteria on unwashed hands during food preparation, or soiled hands reaching the mouth.
Signs and symptoms
The most commonly observed signs associated with ''Shigella'' dysentery include colitis, malnutrition, rectal prolapse, tenesmus, reactive arthritis, and central nervous system problems. Further, ''S. dysenteriae'' is associated with the development of hemolytic-uremic syndrome, which includes anemia, thrombocytopenia, and kidney failure. If infected with ''S. dysenteriae'', an individual will experience a severe case of shigellosis.
Mortality is higher with ''S. dysenteriae'' type 1.] [ Most cases of shigellosis are in developing countries. Shigellosis outbreaks in Asia, Latin America and Africa have had mortality rates of up to 20%.] [
Since the typical fecal specimen is not sterile, the use of selective plates is mandatory. XLD agar, DCA agar, or Hektoen enteric agar are inoculated; all give colorless colonies as the organism is not a lactose fermenter. Inoculation of a TSI slant shows an alkaline slant and acidic, but with no gas, or production. Following incubation on SIM, the culture appears nonmotile with no production. Addition of Kovac's reagent to the SIM tube following growth typically indicates no indole formation (serotypes 2, 7, and 8 produce indole
Mannitol tests yields negative results. [ Ornithine Decarboxylase tests yield negative results.] [
Treatment for shigellosis, independent of the subspecies, requires an antibiotic. Commonly used antibiotics include ampicillin, ciprofloxacin, ceftriaxone, among others. Opioids should be avoided for treatment of Shigellosis.
* Hand washing
at the NCBI Taxonomy Browser
Type strain of ''Shigella dysenteriae''
at BacDive, the Bacterial Diversity Metadatabase
Category:Bacteria described in 1919