Sortilin-related receptor, L(DLR class) A repeats containing is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...

that in humans is encoded by the SORL1

gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...

. SORL1 (also known as SORLA, SORLA1, or LR11) is a

neuron A neuron, neurone, or nerve cell is an electrically excitable cell that communicates with other cells via specialized connections called synapses. The neuron is the main component of nervous tissue in all animals except sponges and placozoa. N ...

apolipoprotein E Apolipoprotein E (APOE) is a protein involved in the metabolism of fats in the body of mammals. A subtype is implicated in Alzheimer's disease and cardiovascular disease. APOE belongs to a family of fat-binding proteins called apolipoproteins. ...

receptor Receptor may refer to: * Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse *Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a ...

, the

for which is predominantly expressed in the central nervous system.

Clinical significance

Mutation of the gene for apolipoprotein E (APOE) is predictive of

Alzheimer's disease Alzheimer's disease (AD) is a neurodegeneration, neurodegenerative disease that usually starts slowly and progressively worsens. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in short-term me ...

. Lack of the APOE receptor is suspected to be a contributory factor to Alzheimer's: a significant reduction in ''SORL1'' (''LR11'')

expression Expression may refer to: Linguistics * Expression (linguistics), a word, phrase, or sentence * Fixed expression, a form of words with a specific meaning * Idiom, a type of fixed expression * Metaphorical expression, a particular word, phrase, o ...

has been found in brain tissue of Alzheimer's disease patients. The APOE receptor has also been linked with regulation of

amyloid precursor protein Amyloid-beta precursor protein (APP) is an integral membrane protein expressed in many biological tissue, tissues and concentrated in the synapses of neurons. It functions as a cell surface receptor and has been implicated as a regulator ...

, faulty processing of which is implicated in Alzheimer's. A more recent study by a group of international researchers supports the proposition that ''SORL1'' plays a part in seniors developing Alzheimer's disease, the findings being significant across racial and ethnic strata.

References

External links

SORL1 references
from NCBI.

N. Wade, New York Times, Jan. 15, 2007. {{DEFAULTSORT:Sorl1 Alzheimer's disease

Clinical significance

See also

References

External links