Solute carrier family 6, member 20 also known as SLC6A20 is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...

which in humans is encoded by the ''SLC6A20''

gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...

Function

Transport of small hydrophilic substances across cell membranes is mediated by substrate-specific transporter proteins which have been classified into several families of related genes. The protein encoded by this gene is a member of the subgroup of transporter with unidentified substrates within the Na⁺ and Cl⁻ coupled transporter family. This gene is expressed in kidney, and its alternative splicing generates 2 transcript variants.

Clinical significance

Mutation in the SLC6A20 gene are associated with iminoglycinuria. One of a cluster of 6 genes ''(SLC6A20'', ''LZTFL1'', ''CCR9'', ''FYCO1'', ''CXCR6'' and ''XCR1'') on chromosome 3 at location 3p21.31 associated with a genetic susceptibility to COVID-19 respiratory failure.

Function

Clinical significance

References

Further reading