Monocarboxylate transporter 6 (MCT6) is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
in humans that is encoded by the SLC16A5
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
This gene encodes a member of the
monocarboxylate transporter The monocarboxylate transporters, or MCTs, are a family of Proton#Hydrogen as proton, proton-linked
Membrane transport protein, plasma membrane transporters that carry molecules having one carboxylate group (monocarboxylates), such as Lactic acid, l ...
family and the
major facilitator superfamily
The major facilitator superfamily (MFS) is a superfamily of membrane transport proteins that facilitate movement of small solutes across cell membranes in response to chemiosmotic gradients.
Function
The major facilitator superfamily (MFS) are ...
. The encoded protein is localized to the
cell membrane
The cell membrane (also known as the plasma membrane (PM) or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates and protects the interior of all cells from the outside environment (t ...
and acts as a proton-linked transporter of
bumetanide. Transport by the encoded protein is inhibited by four loop
diuretics,
nateglinide,
thiazides,
probenecid, and
glibenclamide. Alternative splicing results in multiple
transcript variants
Alternative splicing, or alternative RNA splicing, or differential splicing, is an alternative splicing process during gene expression that allows a single gene to code for multiple proteins. In this process, particular exons of a gene may b ...
.
rovided by RefSeq, Nov 2012
References
Genes on human chromosome 17
Solute carrier family
{{gene-17-stub