South Dakota Highway 251 (SD 251) is a

state route A state highway, state road, or state route (and the equivalent provincial highway, provincial road, or provincial route) is usually a road that is either ''numbered'' or ''maintained'' by a sub-national state or province. A road numbered by a ...

in the U.S. state of

South Dakota South Dakota (; Sioux language, Sioux: , ) is a U.S. state in the West North Central states, North Central region of the United States. It is also part of the Great Plains. South Dakota is named after the Lakota people, Lakota and Dakota peo ...

. SD 251's southern terminus is at the

Nebraska Nebraska () is a state in the Midwestern region of the United States. It is bordered by South Dakota to the north; Iowa to the east and Missouri to the southeast, both across the Missouri River; Kansas to the south; Colorado to the southwe ...

border, and the northern terminus is at

U.S. Route 18 U.S. Route 18 (US 18) is an east–west U.S. highway in the Midwestern United States. The western terminus is in Orin, Wyoming at an interchange with Interstate 25. Its eastern terminus is in downtown Milwaukee, Wisconsin. However, US 18 run ...

Major intersections

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