The Science of Aging Knowledge Environment (SAGE KE) was an
online
In computer technology and telecommunications, online indicates a state of connectivity and offline indicates a disconnected state. In modern terminology, this usually refers to an Internet connection, but (especially when expressed "on line" o ...
scientific
Science is a systematic endeavor that builds and organizes knowledge in the form of testable explanations and predictions about the universe.
Science may be as old as the human species, and some of the earliest archeological evidence for ...
resource provided by the
American Association for the Advancement of Science (AAAS).
History and organization
The American Association for the Advancement of Science established a
collaboration with
Stanford University Libraries and The Center for Resource Economics/Island Press (Island Press) in 1996 to find means to utilize
internet
The Internet (or internet) is the global system of interconnected computer networks that uses the Internet protocol suite (TCP/IP) to communicate between networks and devices. It is a '' network of networks'' that consists of private, pub ...
-based technologies to enhance access to scientific information and improve the effectiveness of information transfer. The collaborative coined the term Knowledge Environment (KE) to describe the collection of
electronic networking tools they were seeking to develop.
SAGE KE is the third in a series of Knowledge Environments developed by ''Science'' and
AAAS, after the
Signal Transduction Knowledge Environment (STKE) and AIDScience. Funding for SAGE KE comes from
The Ellison Medical Foundation, founded and supported by
Oracle Corporation CEO Larry Ellison
Lawrence Joseph Ellison (born August 17, 1944) is an American business magnate and investor who is the co-founder, executive chairman, chief technology officer (CTO) and former chief executive officer (CEO) of the American computer technology ...
.
SAGE KE published its final issue on 28 June 2006 due to lack of funding. The interactive content was discontinued during the summer of 2006, leaving the SAGE KE site as an archive by August 2006.
Activities
The focus of SAGE KE was to provide timely access to information about advances on basic mechanisms of
aging and age-related
disease
A disease is a particular abnormal condition that negatively affects the structure or function of all or part of an organism, and that is not immediately due to any external injury. Diseases are often known to be medical conditions that a ...
s through the
internet
The Internet (or internet) is the global system of interconnected computer networks that uses the Internet protocol suite (TCP/IP) to communicate between networks and devices. It is a '' network of networks'' that consists of private, pub ...
, to provide searchable
database
In computing, a database is an organized collection of data stored and accessed electronically. Small databases can be stored on a file system, while large databases are hosted on computer clusters or cloud storage. The design of databases s ...
s of information on aging and to provide an active environment in which
biogerontologists could share and debate their understandings.
Ouroboros
Ouroboros is a
WordPress
WordPress (WP or WordPress.org) is a free and open-source content management system (CMS) written in hypertext preprocessor language and paired with a MySQL or MariaDB database with supported HTTPS. Features include a plugin architecture ...
community
weblog
A blog (a truncation of "weblog") is a discussion or informational website published on the World Wide Web consisting of discrete, often informal diary-style text entries (posts). Posts are typically displayed in reverse chronological order ...
devoted to research in the
biology of aging. It was established in July 2006 in reaction to the termination of the SAGE KE. The primary mission of the site is to provide timely commentary and review of recently published articles in the scholarly literature, either directly or indirectly related to aging. Articles on the site discuss a range of scientific topics, including
Alzheimer's disease,
bioinformatics,
calorie restriction
Calorie restriction (caloric restriction or energy restriction) is a dietary regimen that reduces intake of energy from caloric foods & beverages without incurring malnutrition. "Reduce" can be defined relative to the subject's previous intake b ...
, regulation of
gene expression, the role of
mitochondria in the aging process, and
evolution
Evolution is change in the heritable characteristics of biological populations over successive generations. These characteristics are the expressions of genes, which are passed on from parent to offspring during reproduction. Variation ...
ary theories of aging.
See also
*
Ageing
*
American Aging Association
The American Aging Association is a non-profit, tax-exempt biogerontology organization of scientists and laypeople dedicated to biomedical aging studies and geroscience, with the goal of slowing the aging process to extend the healthy human lifesp ...
*
Biogerontology
Biogerontology is the sub-field of gerontology concerned with the biological aging process, its evolutionary origins, and potential means to intervene in the process. The term "biogerontology" was coined by S. Rattan, and came in regular use wit ...
*
Science
Science is a systematic endeavor that Scientific method, builds and organizes knowledge in the form of Testability, testable explanations and predictions about the universe.
Science may be as old as the human species, and some of the earli ...
*
Senescence
External links
SAGE KE site archiveOuroboros: Research in the biology of aging
{{DEFAULTSORT:Sage Ke
Gerontology
American Association for the Advancement of Science
Stanford University libraries