Synadenos ( el, Συναδηνός), feminine form Synadene (Συναδηνή), was the name of a middle and late Byzantine aristocratic family, hailing from Synnada in Phrygia, Synada in Phrygia.
The family name is attested in the 9th/10th century seal, but the first known family member is Philetos Synadenos, ''krites'' of Tarsus (city), Tarsus ca. 1000/6. During the 11th and 12th centuries, several family members appear as military commanders, connected to the great aristocratic families of Botaneiates and Komnenos; thus a Synadene, member of the family was given as wife to the Hungarian king Géza I of Hungary, Géza I by Nikephoros III Botaneiates, Basil Synadenos was governor of Dyrrhachium (theme), Dyrrhachium in the 1040s, and Andronikos Synadenos was governor of several provinces under Manuel I Komnenos, including Cyprus.
In the Empire of Nicaea, the Synadenoi were members of the aristocratic opposition to the ruling Laskaris dynasty. The family reached is peak under the Palaiologos, Palaiologan emperors in the late 13th and first half of the 14th century: John Synadenos (megas stratopedarches), John Synadenos married Theodora Palaiologina Synadene, Theodora Palaiologina, the niece of Emperor Michael VIII Palaiologos, and served as ''megas stratopedarches'', and his sons John Synadenos (megas konostaulos), John and Theodore Synadenos, Theodore likewise held senior military commands. The elder John and Theodora also founded the Convent of Bebaia Elpis, and commissioned a splendidly illustrated ''typikon'', with portraits of the family's members. At this time, the Synadenoi intermarried with two other prominent aristocratic families, the Asen (Byzantine family), Asen and the Raoul (Byzantine family), Raoul.
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*{{Polemis-The Doukai, pages=178–182
Synadenos family,