Succinylsulfathiazole (also known as sulfasuxidine) is a
sulfonamide.
It is also spelled as succinylsulphathiazole. It is a white or yellow-white crystalline powder. It dissolves in aqueous solutions of alkali hydroxides and carbonates but is very slightly soluble in water.
It is classified as ultra long-acting drug. About 95% of the drug remains in the intestine and only 5% is hydrolyzed, slowly, to
sulfathiazole and is absorbed.
The drug is used for its antibacterial activity in the GIT. The dose is 10g - 20g daily in divided doses.
The Succinyl group is attached to form a
prodrug for the
controlled release
Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release R, XR, XLdosage) or to a sp ...
of the drug sulfathiazole.
References
2-Thiazolyl compounds
Sulfonamide antibiotics
Anilides
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