''Strychnos nux-vomica'', the strychnine tree, also known as nux vomica, poison fruit, semen strychnos, and quaker buttons, is a
deciduous
In the fields of horticulture and Botany, the term ''deciduous'' () means "falling off at maturity" and "tending to fall off", in reference to trees and shrubs that seasonally shed leaves, usually in the autumn; to the shedding of petals, aft ...
tree
In botany, a tree is a perennial plant with an elongated stem, or trunk, usually supporting branches and leaves. In some usages, the definition of a tree may be narrower, including only woody plants with secondary growth, plants that are ...
native to
India
India, officially the Republic of India (Hindi: ), is a country in South Asia. It is the seventh-largest country by area, the second-most populous country, and the most populous democracy in the world. Bounded by the Indian Ocean on the so ...
and to
southeast Asia
Southeast Asia, also spelled South East Asia and South-East Asia, and also known as Southeastern Asia, South-eastern Asia or SEA, is the geographical United Nations geoscheme for Asia#South-eastern Asia, south-eastern region of Asia, consistin ...
. It is a medium-sized tree in the family
Loganiaceae
The Loganiaceae are a family of flowering plants classified in order Gentianales. The family includes up to 13 genera, distributed around the world's tropics. There are not any great morphological characteristics to distinguish these taxa from o ...
that grows in open habitats. Its
leaves
A leaf (plural, : leaves) is any of the principal appendages of a vascular plant plant stem, stem, usually borne laterally aboveground and specialized for photosynthesis. Leaves are collectively called foliage, as in "autumn foliage", wh ...
are ovate and in size.
It is known for being the natural source of the extremely poisonous compound
strychnine
Strychnine (, , US chiefly ) is a highly toxic, colorless, bitter, crystalline alkaloid used as a pesticide, particularly for killing small vertebrates such as birds and rodents. Strychnine, when inhaled, swallowed, or absorbed through the eye ...
.
Description and properties
![Strychnos nux-vomica 001](https://upload.wikimedia.org/wikipedia/commons/2/2d/Strychnos_nux-vomica_001.JPG)
''Strychnos nux-vomica'' is a medium-sized tree with a short, thick trunk. The wood is dense, hard white, and close-grained. The branches are irregular and are covered with a smooth ashen bark. The young shoots are a deep green colour with a shiny coat. The leaves have an opposite
decussate
Decussation is used in biological contexts to describe a crossing (due to the shape of the Roman numeral for ten, an uppercase 'X' (), ). In Latin anatomical terms, the form is used, e.g. .
Similarly, the anatomical term chiasma is named aft ...
arrangement (each opposing pair of leaves at right angles to the next pair along the stem), are short stalked and oval shaped, have a shiny coat, and are smooth on both sides. The leaves are about long and wide. The flowers are small with a pale green colour and a funnel shape. They bloom in the cold season and have a foul smell. The fruit are about the size of a large apple with a smooth and hard shell that when ripened is a mild shade of orange in colour. The flesh of the fruit is soft and white with a jelly-like pulp containing five seeds covered with a soft, woolly substance.
The seeds have the shape of a flattened disk completely covered with hairs radiating from the center of the sides. This gives the seeds a very characteristic sheen. The seeds are very hard, with a dark gray horny endosperm where the small embryo is housed that gives off no odor but possesses a very bitter taste.
Ecology
The toxic fruit is eaten by monkeys and birds, such as the
gray langur
Gray langurs, also called Hanuman langurs and Hanuman monkeys, are Old World monkeys native to the Indian subcontinent constituting the genus ''Semnopithecus''. Traditionally only one species ''Semnopithecus entellus'' was recognized, but since a ...
.
[ It is also commonly eaten by ]hornbill
Hornbills (Bucerotidae) are a family (biology), family of bird found in tropical and subtropical Africa, Asia and Melanesia. They are characterized by a long, down-curved bill which is frequently brightly coloured and sometimes has a Casque (an ...
species.
Toxicity
It is a major source of the highly poisonous, intensely bitter alkaloid
Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar ...
s strychnine
Strychnine (, , US chiefly ) is a highly toxic, colorless, bitter, crystalline alkaloid used as a pesticide, particularly for killing small vertebrates such as birds and rodents. Strychnine, when inhaled, swallowed, or absorbed through the eye ...
and brucine
Brucine, is an alkaloid closely related to strychnine, most commonly found in the ''Strychnos nux-vomica'' tree. Brucine poisoning is rare, since it is usually ingested with strychnine, and strychnine is more toxic than brucine. In synthetic ch ...
derived from the seeds inside the tree's round, green to orange fruit. The seeds contain approximately 1.5% strychnine, and the dried blossoms contain 1.0%. However, the tree's bark also contains brucine
Brucine, is an alkaloid closely related to strychnine, most commonly found in the ''Strychnos nux-vomica'' tree. Brucine poisoning is rare, since it is usually ingested with strychnine, and strychnine is more toxic than brucine. In synthetic ch ...
and other poisonous compounds.
Uses
The strychnine-containing seeds have been used in arrow poison
Arrow poisons are used to poison arrow heads or darts for the purposes of hunting and warfare. They have been used by indigenous peoples worldwide and are still in use in areas of South America, Africa and Asia. Notable examples are the poisons se ...
. The use of strychnine is highly regulated in many countries, and it is mostly used in baits to kill feral mammals. Most accidental poisoning is caused by breathing in the powder or by absorption through the skin.
''Strychnos'' is promoted within alternative medicine
Alternative medicine is any practice that aims to achieve the healing effects of medicine despite lacking biological plausibility, testability, repeatability, or evidence from clinical trials. Complementary medicine (CM), complementary and alt ...
as a treatment for many conditions, but the claims are not supported by medical evidence.
Herbalism
''Strychnos'' is promoted within herbal medicine
Herbal medicine (also herbalism) is the study of pharmacognosy and the use of medicinal plants, which are a basis of traditional medicine. With worldwide research into pharmacology, some herbal medicines have been translated into modern remed ...
as being a treatment for a wide range of maladies, including cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal b ...
and heart disease
Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels. CVD includes coronary artery diseases (CAD) such as angina and myocardial infarction (commonly known as a heart attack). Other CVDs include stroke, hea ...
.[ There is, however, no evidence it is useful for treating any condition.] Indeed, these seeds contain strychnine. The plant appears on the Commission E The German ''Commission E'' is a scientific advisory board of the Federal Institute for Drugs and Medical Devices formed in 1978. The commission gives scientific expertise for the approval of substances and products previously used in traditional, ...
list of unapproved herbs because it has not been proven to be safe or effective and thus is not recommended for use. Use of strychnine seeds for such purposes may prove fatal as strychnine is a highly toxic compound and has no safe limit for consumption.
In Ayurveda
Ayurveda () is an alternative medicine system with historical roots in the Indian subcontinent. The theory and practice of Ayurveda is pseudoscientific. Ayurveda is heavily practiced in India and Nepal, where around 80% of the population repo ...
(the Indian system of Classical medicine), ''hudar'' is a mixture containing ''Strychnos nux-vomica''. The seeds are first immersed in water for five days and then in milk for two days followed by their boiling in milk.
The level of toxic alkaloids in the unprocessed ''Strychnos'' seeds used in traditional medicines can be determined using established HPLC
High-performance liquid chromatography (HPLC), formerly referred to as high-pressure liquid chromatography, is a technique in analytical chemistry used to separate, identify, and quantify each component in a mixture. It relies on pumps to pa ...
methods and HPLC-UV methods.
References
{{Taxonbar, from=Q272945
Alternative medicine
Medicinal plants
nux-vomica
''Strychnos nux-vomica'', the strychnine tree, also known as nux vomica, poison fruit, semen strychnos, and quaker buttons, is a deciduous tree native to India and to southeast Asia. It is a medium-sized tree in the family Loganiaceae that grows ...
Plants described in 1753
Taxa named by Carl Linnaeus
Strychnine poisoning
Poisonous plants