(−)-Stepholidine is a proto
berberine
Berberine is a quaternary ammonium salt from the protoberberine group of benzylisoquinoline alkaloids found in such plants as ''Berberis vulgaris'' (barberry), '' Berberis aristata'' (tree turmeric), '' Mahonia aquifolium'' (Oregon grape), '' Hyd ...
alkaloid
Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar ...
found in the plant ''
Stephania intermedia''.
Stepholidine activity includes dual
D2 receptor antagonist and
D1 receptor agonist, and has shown
antipsychotic
Antipsychotics, also known as neuroleptics, are a class of psychotropic medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia but also in a range of ...
activity in animal studies.
See also
References
D1-receptor agonists
D2 antagonists
Benzylisoquinoline alkaloids
Phenols
Phenol ethers
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