Stephen Frank Altschul (born February 28, 1957) is an American

mathematician A mathematician is someone who uses an extensive knowledge of mathematics in their work, typically to solve mathematical problems. Mathematicians are concerned with numbers, data, quantity, structure, space, models, and change. History On ...

who has designed

algorithm In mathematics and computer science, an algorithm () is a finite sequence of rigorous instructions, typically used to solve a class of specific Computational problem, problems or to perform a computation. Algorithms are used as specificat ...

s that are used in the field of

bioinformatics Bioinformatics () is an interdisciplinary field that develops methods and software tools for understanding biological data, in particular when the data sets are large and complex. As an interdisciplinary field of science, bioinformatics combi ...

(the Karlin-Altschul algorithm and its successors). Altschul is the co-author of the

BLAST Blast or The Blast may refer to: * Explosion, a rapid increase in volume and release of energy in an extreme manner *Detonation, an exothermic front accelerating through a medium that eventually drives a shock front Film * ''Blast'' (1997 film) ...

algorithm used for

sequence analysis In bioinformatics, sequence analysis is the process of subjecting a DNA, RNA or peptide sequence to any of a wide range of analytical methods to understand its features, function, structure, or evolution. Methodologies used include sequence alignm ...

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...

s and

nucleotide Nucleotides are organic molecules consisting of a nucleoside and a phosphate. They serve as monomeric units of the nucleic acid polymers – deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), both of which are essential biomolecules wi ...

Education

Altschul graduated summa cum laudeNew York Times: "Weddings; Caroline James, Stephen Altschul"
April 17, 1994 from

Harvard University Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher le ...

, where he was elected to

Phi Beta Kappa The Phi Beta Kappa Society () is the oldest academic honor society in the United States, and the most prestigious, due in part to its long history and academic selectivity. Phi Beta Kappa aims to promote and advocate excellence in the liberal a ...

mathematics Mathematics is an area of knowledge that includes the topics of numbers, formulas and related structures, shapes and the spaces in which they are contained, and quantities and their changes. These topics are represented in modern mathematics ...

and has a

Ph.D. A Doctor of Philosophy (PhD, Ph.D., or DPhil; Latin: or ') is the most common degree at the highest academic level awarded following a course of study. PhDs are awarded for programs across the whole breadth of academic fields. Because it is a ...

in the same field from

Massachusetts Institute of Technology The Massachusetts Institute of Technology (MIT) is a private land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a key role in the development of modern technology and science, and is one of the ...

Research

His research interest is centered on sequence alignment algorithms, statistics of sequence comparison and measurement of sequence similarity.

Background

He is the son of Stephanie Rosemary (née Wagner) and

Arthur Altschul Arthur Goodhart Altschul (April 6, 1920 – March 17, 2002) was an American banker and a Goldman Sachs Group partner,Goldman Sachs Goldman Sachs () is an American multinational investment bank and financial services company. Founded in 1869, Goldman Sachs is headquartered at 200 West Street in Lower Manhattan, with regional headquarters in London, Warsaw, Bangalore, H ...

. In 1994, he married Caroline Kershaw James, the daughter of Caroline James-Pritz of

Cincinnati Cincinnati ( ) is a city in the U.S. state of Ohio and the county seat of Hamilton County. Settled in 1788, the city is located at the northern side of the confluence of the Licking and Ohio rivers, the latter of which marks the state line wit ...

and Harry Keithan James of

Dayton, Ohio Dayton () is the sixth-largest city in the U.S. state of Ohio and the county seat of Montgomery County. A small part of the city extends into Greene County. The 2020 U.S. census estimate put the city population at 137,644, while Greater Day ...

. The Rev. Luther D. Miller Jr. performed the ceremony at St. David's Episcopal Church in Washington. His half-sister is journalist

Serena Altschul Serena Altschul (born October 13, 1970) is an American broadcast journalist, known for her work at MTV News and CBS. Early life and education Altschul was born in New York City, a daughter of author and botanist Siri von Reis and Arthur Altsch ...

known for her tenure at

MTV MTV (Originally an initialism of Music Television) is an American cable channel that launched on August 1, 1981. Based in New York City, it serves as the flagship property of the MTV Entertainment Group, part of Paramount Media Networks, a di ...

. On his father's side, he is a member of the

Lehman family The Lehman family is a prominent family of Jewish German-Americans who founded the financial firm Lehman Brothers. Some were also involved in American politics. Members have married into the prominent Morgenthau, Loeb, and Bronfman families. The ...

. He has two sons, James and William Altschul. William Altschul is a former college Ultimate player at Washington University in St. Louis.

From mathematics to bioinformatics

During his undergraduate years, Altschul developed an interest in biology. As a result, he started reading books about DNA. One of the books which he read was ''

The Double Helix ''The Double Helix: A Personal Account of the Discovery of the Structure of DNA'' is an autobiographical account of the discovery of the double helix structure of DNA written by James D. Watson and published in 1968. It has earned both critical ...

'' by Watson. Furthermore, he had also taken a course on Evolutionary Biology. Altschul had also spent two summers working in laboratories at Rockfeller University where he helped to write computer codes for an X-ray crystallography project. Due to his interest, Altschul had considered trying to apply to graduate school in biology. He instead decided to apply to programs in applied mathematics, with the hope of finding some applications of mathematics to biology to work on.

Notable appointments/positions held

Upon graduation, Stephen Frank Altschul worked in the Mathematics Research Branch of the National Institute of Diabetes and Digestive and Kidney Diseases as an IRTA postdoctoral fellowship. From 1990 to present, he has worked in the NCBI Computational Biology Branch, holding the position of senior investigator.

References

External links

highlycited.com
{{DEFAULTSORT:Altschul, Stephen Theoretical biologists American bioinformaticians American people of German-Jewish descent Harvard College alumni 1957 births Living people Lehman family Massachusetts Institute of Technology School of Science alumni